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IPR017046

Source: InterPro

Description

IPR017046 is a Prenylcysteine oxidase 1.

<p>This entry represents prenylcysteine oxidases (also known as prenylcysteine lyases) and homologues that are predicted to have the same function. The human enzyme is part of the lysosome and functions in the degradation of prenylated proteins, cleaving the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine [[cite:PUB00043271], [cite:PUB00100793]]. More recently, prenylcysteine oxidase 1 (PCYOX1) has been found in apoB100-containing lipoproteins, having pro-oxidant activity. It may contribute to development of atherosclerosis, as it is able to generate reactive oxygen species (ROS) and, therefore, contribute lipoproteins oxidation [[cite:PUB00100793], [cite:PUB00100794]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0001735
Molecular function Prenylcysteine oxidase activity Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj1g3v1355770.1
– PREDICTED: farnesylcysteine lyase-like isoform X1 [Cicer arietinum] gi|502137092|ref|XP_004502965.1|
Domains
14
LotjaGi1g1v0322500.1
– Farnesylcysteine lyase; TAIR: AT5G63910.1 farnesylcysteine lyase; Swiss-Prot: sp|P57681|PCYOX_ARATH Farnesylcysteine lyase; TrEMBL-Plants: tr|A0A151RY30|A0A151RY30_CAJCA Putative prenylcysteine oxidase; Found in the gene: LotjaGi1g1v0322500
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF51905 SUPERFAMILY 1 50.00