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IPR017104 is a Adaptor protein complex AP-2, alpha subunit.
<p>Adaptor protein complex AP-2 has a role in clathrin-mediated endocytosis and intracellular transport [[cite:PUB00088085]]. AP-2 links clathrin to membrane lipids and transmembrane cargoes at the vesicle budding site [[cite:PUB00088083]]. It consists of two large subunits termed adaptins (alpha and beta subunits), a medium-sized one (mu), and a small one (sigma). It is thought to act in cargo selection by interaction with selection motifs encoded in the cytoplasmic tails of cargo molecules. The N-terminal domains of the adaptins, together with the mu and sigma subunits, constitute the 'head' of the adaptor, which interacts with plasma membrane lipids and cargoes. AP-2 plays a role in the recycling of synaptic vesicle membranes from the presynaptic surface [[cite:PUB00088084]].</p> <p>This family represents the alpha subunit of adaptor protein complex AP-2.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | ||
| Cellular component | AP-2 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). | ||
| Molecular function | Clathrin adaptor activity | The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way. | ||
| Biological process | Clathrin-dependent endocytosis | An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | AP-2 complex subunit alpha; TAIR: AT5G22770.1 alpha-adaptin; Swiss-Prot: sp|Q8LPL6|AP2A1_ARATH AP-2 complex subunit alpha-1; TrEMBL-Plants: tr|A0A151RV94|A0A151RV94_CAJCA AP-2 complex subunit alpha; Found in the gene: LotjaGi3g1v0172200 | 23 | ||
| – | AP-2 complex subunit alpha; TAIR: AT5G22770.1 alpha-adaptin; Swiss-Prot: sp|Q8LPL6|AP2A1_ARATH AP-2 complex subunit alpha-1; TrEMBL-Plants: tr|A0A151RV94|A0A151RV94_CAJCA AP-2 complex subunit alpha; Found in the gene: LotjaGi3g1v0172200 | 23 | ||
| – | AP-2 complex subunit alpha; TAIR: AT5G22770.1 alpha-adaptin; Swiss-Prot: sp|Q8LPL6|AP2A1_ARATH AP-2 complex subunit alpha-1; TrEMBL-Plants: tr|A0A151RV94|A0A151RV94_CAJCA AP-2 complex subunit alpha; Found in the gene: LotjaGi3g1v0172200 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |