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IPR017105 is a Adaptor protein complex AP-3, delta subunit.
<p>The adaptor protein complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 3 (AP-3) appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.</p> <p>AP-3 is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). The subunits of non-clathrin- and clathrin-associated adaptor protein complex 3 play a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or in endosomes.</p> <p>This group represents an adaptor protein complex AP-3, delta subunit.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | ||
| Cellular component | AP-3 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: AP-3 complex subunit delta-like [Cicer arietinum] gi|502163538|ref|XP_004512869.1| | 11 | ||
| – | AP-3 complex subunit delta; TAIR: AT1G48760.1 delta-adaptin; Swiss-Prot: sp|Q9C744|AP3D_ARATH AP-3 complex subunit delta; TrEMBL-Plants: tr|G7L9R3|G7L9R3_MEDTR AP-3 complex subunit delta; Found in the gene: LotjaGi6g1v0173900 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |