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IPR018094 is a Thymidylate kinase.
<p>Thymidylate kinase ([ec:2.7.4.9]; dTMP kinase) catalyses the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:</p> <p><reaction> ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate </reaction></p> <p>Thymidylate kinase is an ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages [[cite:PUB00016913]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Thymidylate kinase activity | Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | DTDP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: thymidylate kinase-like isoform X3 [Cicer arietinum] gi|502084498|ref|XP_004487702.1| | 9 | ||
| – | Thymidylate kinase [Medicago truncatula] gi|357452915|ref|XP_003596734.1| | 11 | ||
| – | Thymidylate kinase; TAIR: AT5G59440.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q0WW55|ZEUS1_ARATH Thymidylate kinase; TrEMBL-Plants: tr|C6TJ88|C6TJ88_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0266400_LC | 13 | ||
| – | Thymidylate kinase; TAIR: AT5G59440.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q0WW55|ZEUS1_ARATH Thymidylate kinase; TrEMBL-Plants: tr|A0A072TF88|A0A072TF88_MEDTR p-loop nucleoside triphosphate hydrolase superfamily protein; Found in the gene: LotjaGi5g1v0210400 | 13 | ||
| – | Thymidylate kinase; TAIR: AT5G59440.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q0WW55|ZEUS1_ARATH Thymidylate kinase; TrEMBL-Plants: tr|A0A072TF88|A0A072TF88_MEDTR p-loop nucleoside triphosphate hydrolase superfamily protein; Found in the gene: LotjaGi5g1v0210400 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01672 | CDD | 1 | 20.00 |