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IPR018146 is a Glyoxalase I, conserved site.
<p>Glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway in the following reaction:</p> <p><reaction> glutathione + methylglyoxal = (R)-S-lactoylglutathione </reaction></p> <p>S-lactoylglutathione is then converted by glyoxalase II to lactic acid [[cite:PUB00002779]]. Glyoxalase I is a ubiquitous enzyme which binds one mole of zinc per subunit. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric. The sequence of glyoxalase I is well conserved. In bacteria and mammals the enzyme is a protein of about 130 to 180 residues while in fungi it is about twice as long. In these organisms the enzyme is built out of the tandem repeat of a homologous domain.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Lactoylglutathione lyase activity | Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. | ||
| Molecular function | Metal ion binding | Interacting selectively and non-covalently with any metal ion. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable lactoylglutathione lyase, chloroplast-like [Glycine max] gi|356507913|ref|XP_003522707.1| | 19 | ||
| – | PREDICTED: probable lactoylglutathione lyase, chloroplast-like [Glycine max] gi|356529638|ref|XP_003533396.1| | 12 | ||
| – | PREDICTED: lactoylglutathione lyase-like [Glycine max] gi|356542658|ref|XP_003539783.1| | 13 | ||
| – | Lactoylglutathione lyase [Medicago truncatula] gi|357480323|ref|XP_003610447.1| | 12 | ||
| – | PREDICTED: probable lactoylglutathione lyase, chloroplast-like isoform X2 [Cicer arietinum] gi|502138585|ref|XP_004503462.1| | 14 | ||
| – | PREDICTED: probable lactoylglutathione lyase, chloroplast-like isoform X1 [Cicer arietinum] gi|502138583|ref|XP_004503461.1| | 13 | ||
| – | Lactoylglutathione lyase [Gossypium hirsutum] gi|211906514|gb|ACJ11750.1| | 12 | ||
| – | Lactoylglutathione lyase [Gossypium hirsutum] gi|211906514|gb|ACJ11750.1| | 12 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G67280.1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein; Swiss-Prot: sp|Q8W593|LGUC_ARATH Probable lactoylglutathione lyase, chloroplastic; TrEMBL-Plants: tr|I1JUU8|I1JUU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0404100 | 20 | ||
| – | Lactoylglutathione lyase-like protein; TAIR: AT1G67280.1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein; Swiss-Prot: sp|Q8W593|LGUC_ARATH Probable lactoylglutathione lyase, chloroplastic; TrEMBL-Plants: tr|I1L4L5|I1L4L5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0221400 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G08110.4 lactoylglutathione lyase family protein / glyoxalase I family protein; Swiss-Prot: sp|Q9ZS21|LGUL_SOYBN Lactoylglutathione lyase; TrEMBL-Plants: tr|V7AGB4|V7AGB4_PHAVU Lactoylglutathione lyase; Found in the gene: LotjaGi3g1v0486600 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G08110.1 lactoylglutathione lyase family protein / glyoxalase I family protein; Swiss-Prot: sp|Q9ZS21|LGUL_SOYBN Lactoylglutathione lyase; TrEMBL-Plants: tr|I3T0P3|I3T0P3_LOTJA Lactoylglutathione lyase; Found in the gene: LotjaGi3g1v0486600 | 16 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G08110.4 lactoylglutathione lyase family protein / glyoxalase I family protein; Swiss-Prot: sp|Q9ZS21|LGUL_SOYBN Lactoylglutathione lyase; TrEMBL-Plants: tr|I1LL14|I1LL14_SOYBN Lactoylglutathione lyase; Found in the gene: LotjaGi3g1v0486600 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G11840.6 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Swiss-Prot: sp|Q39366|LGUL_BRAOG Putative lactoylglutathione lyase; TrEMBL-Plants: tr|A0A151SU07|A0A151SU07_CAJCA Putative lactoylglutathione lyase; Found in the gene: LotjaGi4g1v0013800 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G11840.6 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Swiss-Prot: sp|Q39366|LGUL_BRAOG Putative lactoylglutathione lyase; TrEMBL-Plants: tr|I1KNE1|I1KNE1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0013800 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G11840.6 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Swiss-Prot: sp|Q39366|LGUL_BRAOG Putative lactoylglutathione lyase; TrEMBL-Plants: tr|I1KNE1|I1KNE1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0013800 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G67280.1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein; Swiss-Prot: sp|Q8W593|LGUC_ARATH Probable lactoylglutathione lyase, chloroplastic; TrEMBL-Plants: tr|I3TAJ8|I3TAJ8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0447100 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G67280.1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein; Swiss-Prot: sp|Q8W593|LGUC_ARATH Probable lactoylglutathione lyase, chloroplastic; TrEMBL-Plants: tr|I3TAJ8|I3TAJ8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0447100 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G67280.1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein; Swiss-Prot: sp|Q8W593|LGUC_ARATH Probable lactoylglutathione lyase, chloroplastic; TrEMBL-Plants: tr|I3TAJ8|I3TAJ8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0447100 | 14 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G67280.1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein; Swiss-Prot: sp|Q8W593|LGUC_ARATH Probable lactoylglutathione lyase, chloroplastic; TrEMBL-Plants: tr|I3TAJ8|I3TAJ8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0447100 | 14 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G11840.6 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Swiss-Prot: sp|Q39366|LGUL_BRAOG Putative lactoylglutathione lyase; TrEMBL-Plants: tr|I3T6L8|I3T6L8_LOTJA Lactoylglutathione lyase; Found in the gene: LotjaGi6g1v0294200 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G11840.6 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Swiss-Prot: sp|Q39366|LGUL_BRAOG Putative lactoylglutathione lyase; TrEMBL-Plants: tr|I3T6L8|I3T6L8_LOTJA Lactoylglutathione lyase; Found in the gene: LotjaGi6g1v0294200 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G11840.6 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Swiss-Prot: sp|Q39366|LGUL_BRAOG Putative lactoylglutathione lyase; TrEMBL-Plants: tr|I3T6L8|I3T6L8_LOTJA Lactoylglutathione lyase; Found in the gene: LotjaGi6g1v0294200 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G11840.6 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Swiss-Prot: sp|Q39366|LGUL_BRAOG Putative lactoylglutathione lyase; TrEMBL-Plants: tr|I3T6L8|I3T6L8_LOTJA Lactoylglutathione lyase; Found in the gene: LotjaGi6g1v0294200 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G11840.6 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Swiss-Prot: sp|Q39366|LGUL_BRAOG Putative lactoylglutathione lyase; TrEMBL-Plants: tr|I3T6L8|I3T6L8_LOTJA Lactoylglutathione lyase; Found in the gene: LotjaGi6g1v0294200 | 15 | ||
| – | Lactoylglutathione lyase; TAIR: AT1G11840.6 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Swiss-Prot: sp|Q39366|LGUL_BRAOG Putative lactoylglutathione lyase; TrEMBL-Plants: tr|I3T6L8|I3T6L8_LOTJA Lactoylglutathione lyase; Found in the gene: LotjaGi6g1v0294200 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16358 | CDD | 1 | 3.85 |