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IPR018236 is a SAICAR synthetase, conserved site.
<p>Phosphoribosylaminoimidazole-succinocarboxamide synthase ([ec:6.3.2.6]) (SAICAR synthetase) catalyses the seventh step in the<i>de novo</i>purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [[cite:PUB00004940], [cite:PUB00070198]].</p> <p>In bacteria (purC), fungi (ADE1) and plants (Pur7), SAICAR synthetase is a monofunctional protein; in animals it is the N-terminal domain of a bifunctional enzyme that also catalyse phosphoribosylaminoimidazole carboxylase (AIRC) activity (see [interpro:IPR000031]).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate. | ||
| Biological process | Purine nucleotide biosynthetic process | The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic-like [Cicer arietinum] gi|502144710|ref|XP_004505724.1| | 12 | ||
| – | PREDICTED: phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic-like [Cicer arietinum] gi|502144710|ref|XP_004505724.1| | 14 | ||
| – | PREDICTED: phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic-like [Glycine max] gi|356552941|ref|XP_003544818.1| | 9 | ||
| – | Phosphoribosylaminoimidazole-succinocarboxamide synthase; TAIR: AT3G21110.1 purin 7; Swiss-Prot: sp|Q07463|PUR7_VIGAC Phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic; TrEMBL-Plants: tr|I1MAX9|I1MAX9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0140400 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |