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IPR018276 is a DET1- and DDB1-associated protein 1 domain.
<p>This entry represents the DDA1 domain described in DET1- and DDB1-associated protein 1 ubiquitin ligases.</p> <p>DDA1 is a core subunit of multiple Cul4-based E3 ligases (CRL4s), involved in ubiquitination and subsequent proteasomal degradation of target proteins, which regulate key developmental and stress responses in eukaryotes [[cite:PUB00079134], [cite:PUB00079133]]. In mammals, DDA1 binds to DET1 and DDB1 to form DDD complexes, which recruit specific ubiquitin-conjugating UBE2E enzymes to form DDD-E2 complexes [[cite:PUB00044222]]. The DDD-E2 complex provides a platform for interaction with Cul4A and beta-transducing (also called WD40) repeat proteins. DDA1 is conserved in higher eukaryotes, including Arabidopsis [[cite:PUB00079133]]. This entry also includes protein LOWER TEMPERATURE 1 (LOT1) from Arabidopsis which contains the conserved DDA1 domain. LOT1 supports abscisic acid (ABA) responses and drought tolerance by regulating the dynamic localization and stability (preventing degradation by the proteasome) of CAR proteins (C2-domain ABA-related, e.g. CAR9) [[cite:PUB00153154]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Os03g0125700 [Oryza sativa Japonica Group] gi|115450437|ref|NP_001048819.1| | 6 | ||
| – | SAP domain-containing protein [Arabidopsis thaliana] gi|42568735|ref|NP_201151.2| | 3 | ||
| – | SAP domain-containing protein [Arabidopsis thaliana] gi|42568735|ref|NP_201151.2| | 10 | ||
| – | SAP domain-containing protein; TAIR: AT5G63460.1 SAP domain-containing protein; Swiss-Prot: sp|Q2H0I3|KU70_CHAGB ATP-dependent DNA helicase II subunit 1; TrEMBL-Plants: tr|I3S8N0|I3S8N0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0222300 | 11 | ||
| – | SAP domain-containing protein; TAIR: AT5G63460.1 SAP domain-containing protein; Swiss-Prot: sp|O74871|YCW3_SCHPO Uncharacterized protein C31H12.03c; TrEMBL-Plants: tr|I3S8N0|I3S8N0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0222300 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |