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IPR018487 is a Hemopexin-like repeats.
<p>Hemopexin ([ec:3.2.1.35]) is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation [[cite:PUB00013985]]. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. Hemopexin-like domains have been found in two other types of proteins, vitronectin [[cite:PUB00013984]], a cell adhesion and spreading factor found in plasma and tissues, and matrixins MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15 and MMP-16, members of the matrix metalloproteinase family that cleave extracellular matrix constituents [[cite:PUB00013983]]. These zinc endopeptidases, which belong to MEROPS peptidase subfamily M10A, have a single hemopexin-like domain in their C-terminal section. It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).</p> <p>The hemopexin domain exhibits the shape of an oblate ellipsoidal disk. The polypeptide chain is organised in four β-sheet (blades) I to IV, which are almost symmetrically arranged around a central axis in consecutive order, giving rise to the formation of a four-bladed propeller. Each propeller blade or repeat is made up of four antiparallel β-strands connected in a W-like strand topology, and is strongly twisted [[cite:PUB00003374], [cite:PUB00068726]].</p> <p>This entry represents the repeats found in hemopexin and related domains.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Albumin-2 [Medicago truncatula] gi|357514901|ref|XP_003627739.1| | 7 | ||
| – | PREDICTED: albumin-2-like [Cicer arietinum] gi|502181747|ref|XP_004516876.1| | 7 | ||
| – | Pierisin [Medicago truncatula] gi|357514961|ref|XP_003627769.1| | 13 | ||
| – | Pierisin [Medicago truncatula] gi|357514961|ref|XP_003627769.1| | 13 | ||
| – | Albumin-2 [Medicago truncatula] gi|357514901|ref|XP_003627739.1| | 7 | ||
| – | Albumin-2 [Medicago truncatula] gi|357514901|ref|XP_003627739.1| | 6 | ||
| – | Albumin-2, partial [Medicago truncatula] gi|357439061|ref|XP_003589807.1| | 7 | ||
| – | Pierisin [Medicago truncatula] gi|357514961|ref|XP_003627769.1| | 7 | ||
| – | Albumin-2 protein; TAIR: AT1G54450.1 Calcium-binding EF-hand family protein; Swiss-Prot: sp|P08688|ALB2_PEA Albumin-2; TrEMBL-Plants: tr|G7LEK7|G7LEK7_MEDTR Albumin-2 protein; Found in the gene: LotjaGi1g1v0014300 | 7 | ||
| – | Albumin-2 protein; Swiss-Prot: sp|P08688|ALB2_PEA Albumin-2; TrEMBL-Plants: tr|Q1RU99|Q1RU99_MEDTR Albumin-2 protein; Found in the gene: LotjaGi1g1v0014400_LC | 6 | ||
| – | Albumin-2 protein; TAIR: AT3G18660.1 plant glycogenin-like starch initiation protein 1; Swiss-Prot: sp|P08688|ALB2_PEA Albumin-2; TrEMBL-Plants: tr|Q1RU99|Q1RU99_MEDTR Albumin-2 protein; Found in the gene: LotjaGi3g1v0067400_LC | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF56399 | SUPERFAMILY | 1 | 9.09 |