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IPR018488 is a Cyclic nucleotide-binding, conserved site.
<p>Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [[cite:PUB00013967], [cite:PUB00013968], [cite:PUB00005543]]. The best studied of these proteins is the prokaryotic catabolite gene activator (also known as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three α-helices and a distinctive eight-stranded, antiparallel β-barrel structure. There are six invariant amino acids in this domain, three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the β-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such cations channels have been fully characterised, one is found in rod cells where it plays a role in visual signal transduction.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable cyclic nucleotide-gated ion channel 14-like [Cicer arietinum] gi|502132108|ref|XP_004501229.1| | 20 | ||
| – | PREDICTED: acyl-coenzyme A thioesterase 8-like isoform 1 [Glycine max] gi|356532006|ref|XP_003534565.1| | 19 | ||
| – | Cyclic nucleotide-gated channel; TAIR: AT2G24610.1 cyclic nucleotide-gated channel 14; Swiss-Prot: sp|Q9SJA4|CNG14_ARATH Probable cyclic nucleotide-gated ion channel 14; TrEMBL-Plants: tr|V7AWW4|V7AWW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0396000 | 24 | ||
| – | Acyl-CoA thioesterase; TAIR: AT1G01710.1 acyl-CoA thioesterase II; Swiss-Prot: sp|P58137|ACOT8_MOUSE Acyl-coenzyme A thioesterase 8; TrEMBL-Plants: tr|A0A0L9TCU4|A0A0L9TCU4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0475300 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03445 | CDD | 1 | 25.00 |