Description

IPR003938 is a Potassium channel, voltage-dependent, EAG/ELK/ERG-like.

<p>The first EAG K+ channel was identified in Drosophila melanogaster (Fruit fly), following a screening for mutations giving rise to behavioural abnormalities. Disruption of the Eag gene caused an ether-induced, leg-shaking behaviour. Subsequent studies have revealed a conserved multi-gene family of EAG-like K+ channels, which are present in human and many other species. Based on the varying functional properties of the channels, the family has been divided into 3 subfamilies: EAG, ELK and ERG. Interestingly, Caenorhabditis elegans appears to lack the ELK type [[cite:PUB00007312]].</p> <p>Potassium channels are the most diverse group of the ion channel family [[cite:PUB00001055], [cite:PUB00001622]]. They are important in shaping the action potential, and in neuronal excitability and plasticity [[cite:PUB00004020]]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [[cite:PUB00006577]]: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group.</p> <p>These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and toxin binding properties. Each type of K<SUP>+</SUP>channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter, together with intracellular kinases; while others are regulated by GTP-binding proteins or other second messengers [[cite:PUB00004011]]. In eukaryotic cells, K<SUP>+</SUP>channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes [[cite:PUB00002771]]. In prokaryotic cells, they play a role in the maintenance of ionic homeostasis [[cite:PUB00009378]].</p> <p>All K<SUP>+</SUP>channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which has been termed the K<SUP>+</SUP>selectivity sequence. In families that contain one P-domain, four subunits assemble to form a selective pathway for K<SUP>+</SUP>across the membrane. However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo-or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K<SUP>+</SUP>channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K<SUP>+</SUP>channels; and three types of calcium (Ca)-activated K<SUP>+</SUP>channels (BK, IK and SK) [[cite:PUB00009378]]. The 2TM domain family comprises inward-rectifying K<SUP>+</SUP>channels. In addition, there are K<SUP>+</SUP>channel alpha-subunits that possess two P-domains. These are usually highly regulated K<SUP>+</SUP>selective leak channels.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 41

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: