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IPR018607 is a Chromosome transmission fidelity protein 8.
<p>Ctf8 is a component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC [[cite:PUB00045276], [cite:PUB00045277]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Mitotic sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. | ||
| Cellular component | Ctf18 RFC-like complex | A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: chromosome transmission fidelity protein 8 homolog [Glycine max] gi|356559833|ref|XP_003548201.1| | 3 | ||
| – | Chromosome transmission fidelity protein 8; TAIR: AT5G52220.1 chromosome transmission fidelity-like protein; Swiss-Prot: sp|P0CG15|CTF8_MOUSE Chromosome transmission fidelity protein 8 homolog; TrEMBL-Plants: tr|I1MPY4|I1MPY4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0145300 | 3 | ||
| – | Chromosome transmission fidelity protein 8; TAIR: AT5G52220.1 chromosome transmission fidelity-like protein; Swiss-Prot: sp|P0CG15|CTF8_MOUSE Chromosome transmission fidelity protein 8 homolog; TrEMBL-Plants: tr|A0A0S3TAX3|A0A0S3TAX3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0145300 | 3 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR47475 | PANTHER | 1 | 33.33 |