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IPR018619 is a Hyccin.
<p>This family hyccin proteins (HYCC1/2) which are a component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane and it also regulates phosphatidylinositol 4-phosphate (PtdIns4P) synthesis [[cite:PUB00090096]]. HYCC1 plays a key role in oligodendrocytes formation [[cite:PUB00090096]] which may explain its importance in myelination of the central and peripheral nervous system [[cite:PUB00044307]]. Defects in Hyccin are the cause of hypomyelination with congenital cataracts [OMIM:610532]. This disorder is characterised by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs [[cite:PUB00044307], [cite:PUB00044308]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Hyccin [Medicago truncatula] gi|357493573|ref|XP_003617075.1| | 4 | ||
| – | Uncharacterized protein TCM_007521 [Theobroma cacao] gi|508706945|gb|EOX98841.1| | 8 | ||
| – | Hyccin protein; TAIR: AT5G21050.1 hyccin; Swiss-Prot: sp|Q6P121|HYCCI_DANRE Hyccin; TrEMBL-Plants: tr|A0A072UY98|A0A072UY98_MEDTR Hyccin protein; Found in the gene: LotjaGi1g1v0057800 | 5 | ||
| – | Hyccin protein; TAIR: AT5G64090.1 hyccin; Swiss-Prot: sp|Q6P121|HYCCI_DANRE Hyccin; TrEMBL-Plants: tr|A0A072UZE2|A0A072UZE2_MEDTR Hyccin protein; Found in the gene: LotjaGi4g1v0033700 | 8 | ||
| – | Hyccin protein; TAIR: AT5G64090.1 hyccin; Swiss-Prot: sp|Q6P121|HYCCI_DANRE Hyccin; TrEMBL-Plants: tr|A0A072UZE2|A0A072UZE2_MEDTR Hyccin protein; Found in the gene: LotjaGi4g1v0033700 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |