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IPR018848 is a WIYLD domain.
<p>This entry represents the plant-specific WIYLD domain, named based on the pattern of the most conserved residues [[cite:PUB00044540], [cite:PUB00103774]]. This is a ubiquitin-binding domain that adopts a four-helix bundle structure, in contrast to the three-helix bundles of other ubiquitin binding domains. It is found in histone-lysine N-methyltransferase SUVR4 and related proteins SUVR1 and SUVR2. SUVR4 is an active histone methyltransferase with a preference for H3K9me1 [[cite:PUB00044540]] and ubiquitin binding mediated by this domain facilitates the addition of two methyl groups to monomethylated lysine 9 of histone H3 [[cite:PUB00103774]]. SUVR2 has no histone methyltransferase activity and is involved in transcriptional gene silencing [[cite:PUB00077095]]. SUVR2 forms a complex with SUVR1 and associates with the SNF2-related chromatin-remodeling proteins. No histone methyltransferase activity has been detected for SUVR1 neither [[cite:PUB00044540]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Histone-lysine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: histone-lysine N-methyltransferase SUVR4-like [Glycine max] gi|356533657|ref|XP_003535377.1| | 17 | ||
| – | PREDICTED: histone-lysine N-methyltransferase SUVR4-like [Glycine max] gi|356533657|ref|XP_003535377.1| | 14 | ||
| – | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 [Medicago truncatula] gi|357505017|ref|XP_003622797.1| | 18 | ||
| – | PREDICTED: histone-lysine N-methyltransferase SUVR1-like [Glycine max] gi|356536852|ref|XP_003536947.1| | 17 | ||
| – | PREDICTED: histone-lysine N-methyltransferase SUVR4-like isoform X1 [Cicer arietinum] gi|502110178|ref|XP_004493818.1| | 17 | ||
| – | Uncharacterized protein TCM_042566 [Theobroma cacao] gi|508725959|gb|EOY17856.1| | 4 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT2G40020.2 Nucleolar histone methyltransferase-related protein; Swiss-Prot: sp|Q946J2|SUVR1_ARATH Probable inactive histone-lysine N-methyltransferase SUVR1; TrEMBL-Plants: tr|A0A0L9UWG4|A0A0L9UWG4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0078800 | 5 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT3G04380.1 SET-domain containing protein lysine methyltransferase family protein; Swiss-Prot: sp|Q8W595|SUVR4_ARATH Histone-lysine N-methyltransferase SUVR4; TrEMBL-Plants: tr|K7MYR2|K7MYR2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0704900 | 18 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT3G04380.1 SET-domain containing protein lysine methyltransferase family protein; Swiss-Prot: sp|Q8W595|SUVR4_ARATH Histone-lysine N-methyltransferase SUVR4; TrEMBL-Plants: tr|K7MYR2|K7MYR2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0704900 | 18 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT5G13960.1 histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein; Swiss-Prot: sp|Q8GZB6|SUVH4_ARATH Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4; TrEMBL-Plants: tr|G7KY38|G7KY38_MEDTR SET-domain protein lysine methyltransferase family protein, putative; Found in the gene: LotjaGi2g1v0222100_LC | 19 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT5G13960.1 histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein; Swiss-Prot: sp|Q8GZB6|SUVH4_ARATH Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4; TrEMBL-Plants: tr|G7KY38|G7KY38_MEDTR SET-domain protein lysine methyltransferase family protein, putative; Found in the gene: LotjaGi2g1v0222100_LC | 19 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT5G43990.1 SET-domain containing protein lysine methyltransferase family protein; Swiss-Prot: sp|Q9FNC7|SUVR2_ARATH Probable inactive histone-lysine N-methyltransferase SUVR2; TrEMBL-Plants: tr|A0A0B2PE63|A0A0B2PE63_GLYSO Histone-lysine N-methyltransferase SUVR2; Found in the gene: LotjaGi5g1v0153400 | 18 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT3G04380.1 SET-domain containing protein lysine methyltransferase family protein; Swiss-Prot: sp|Q8W595|SUVR4_ARATH Histone-lysine N-methyltransferase SUVR4; TrEMBL-Plants: tr|K7N541|K7N541_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0209600 | 17 | ||
| – | Nucleolar histone methyltransferase-related protein; TAIR: AT2G40020.3 Nucleolar histone methyltransferase-related protein; Swiss-Prot: sp|A7SG73|NADC_NEMVE Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TrEMBL-Plants: tr|A0A072VNQ1|A0A072VNQ1_MEDTR Ubiquitin-binding WIYLD domain protein; Found in the gene: LotjaGi5g1v0215700_LC | 9 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT2G40020.2 Nucleolar histone methyltransferase-related protein; Swiss-Prot: sp|Q946J2|SUVR1_ARATH Probable inactive histone-lysine N-methyltransferase SUVR1; TrEMBL-Plants: tr|K7N558|K7N558_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0216000 | 3 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR34271 | PANTHER | 1 | 6.67 |