Domain Predictions — View

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IPR019137

Source: InterPro

Description

IPR019137 is a Nck-associated protein 1.

<p>Nck-associated protein 1 is part of lamellipodial complex that controls Rac-dependent actin remodeling [[cite:PUB00098480], [cite:PUB00098479]]. It associates preferentially with the first SH3 domain of Nck and is a component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. It is also a component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease [[cite:PUB00044392]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 8

Transcript	Name	Description	Predicted domains	Domain count
Lj4g3v0654410.1 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	LjNap	Nck-associated protein 1 [Lotus japonicus] gi\|221272640\|emb\|CAQ17051.1\|	Domains Coil IPR019137 PF09735 PTHR12093 PTHR12093:SF10 mobidb-lite	6
Lj4g3v0654410.2 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–		Domains IPR019137 PF09735 PTHR12093 PTHR12093:SF10 mobidb-lite	5
Lj5g3v0309130.1 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Nck-associated protein 1 [Lotus japonicus] gi\|221272640\|emb\|CAQ17051.1\|	Domains Coil IPR019137 PF09735 PTHR12093 mobidb-lite	5
LotjaGi4g1v0083200.1 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Nck-associated protein 1; TAIR: AT2G35110.2 transcription activator; Swiss-Prot: sp\|Q5S2C4\|NCKP1_ARATH Protein NAP1; TrEMBL-Plants: tr\|B7ZGK2\|B7ZGK2_LOTJA Nck-associated protein 1; Found in the gene: LotjaGi4g1v0083200	Domains Coil IPR019137 PF09735 PTHR12093 PTHR12093:SF10 mobidb-lite	6
LotjaGi4g1v0083200.2 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Nck-associated protein 1; TAIR: AT2G35110.2 transcription activator; Swiss-Prot: sp\|Q5S2C4\|NCKP1_ARATH Protein NAP1; TrEMBL-Plants: tr\|B7ZGK2\|B7ZGK2_LOTJA Nck-associated protein 1; Found in the gene: LotjaGi4g1v0083200	Domains Coil IPR019137 PF09735 PTHR12093 PTHR12093:SF10 mobidb-lite	6
LotjaGi4g1v0083200.3 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Nck-associated protein 1; TAIR: AT2G35110.2 transcription activator; Swiss-Prot: sp\|Q5S2C4\|NCKP1_ARATH Protein NAP1; TrEMBL-Plants: tr\|B7ZGK2\|B7ZGK2_LOTJA Nck-associated protein 1; Found in the gene: LotjaGi4g1v0083200	Domains Coil IPR019137 PF09735 PTHR12093 PTHR12093:SF10 mobidb-lite	6
LotjaGi4g1v0083200.4 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	NAP1; TAIR: AT2G35110.1 transcription activator; Swiss-Prot: sp\|Q5S2C4\|NCKP1_ARATH Protein NAP1; TrEMBL-Plants: tr\|B7ZGK5\|B7ZGK5_LOTJA Nck-associated protein 1; Found in the gene: LotjaGi4g1v0083200	Domains IPR019137 PF09735 PTHR12093 PTHR12093:SF10 mobidb-lite	5
LotjaGi4g1v0083200.5 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	NAP1; TAIR: AT2G35110.1 transcription activator; Swiss-Prot: sp\|Q5S2C4\|NCKP1_ARATH Protein NAP1; TrEMBL-Plants: tr\|B7ZGK5\|B7ZGK5_LOTJA Nck-associated protein 1; Found in the gene: LotjaGi4g1v0083200	Domains IPR019137 PF09735 PTHR12093 PTHR12093:SF10 mobidb-lite	5

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain	Source	Observations	Saturation (%)
mobidb-lite	MobiDBLite	1	12.50