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IPR019145 is a Mediator complex, subunit Med10.
<p>The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.</p> <p>The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11.</p> <p>Med10 is one of the protein subunits of the Mediator complex, tethered to Med14 (Rgr1) protein. Med10 specifically mediates basal-level HIS4 transcription via Gcn4. In addition, there is a putative requirement for Med10 in Bas2-mediated transcription [[cite:PUB00044353]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Transcription coregulator activity | A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators. | ||
| Biological process | Regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. | ||
| Cellular component | Mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: mediator of RNA polymerase II transcription subunit 10b-like [Cicer arietinum] gi|502087334|ref|XP_004488501.1| | 4 | ||
| – | PREDICTED: mediator of RNA polymerase II transcription subunit 10b-like isoform X2 [Cicer arietinum] gi|502140788|ref|XP_004504338.1| | 3 | ||
| – | Mediator of RNA polymerase II transcription subunit 10; TAIR: AT1G26665.1 Mediator complex, subunit Med10; Swiss-Prot: sp|F4HPA7|MD10B_ARATH Mediator of RNA polymerase II transcription subunit 10b; TrEMBL-Plants: tr|I3SQ83|I3SQ83_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0094500 | 5 | ||
| – | Mediator of RNA polymerase II transcription subunit 10; TAIR: AT1G26665.1 Mediator complex, subunit Med10; Swiss-Prot: sp|F4HPA7|MD10B_ARATH Mediator of RNA polymerase II transcription subunit 10b; TrEMBL-Plants: tr|C6TKB8|C6TKB8_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0374100 | 4 | ||
| – | Mediator of RNA polymerase II transcription subunit 10; TAIR: AT1G26665.1 Mediator complex, subunit Med10; Swiss-Prot: sp|F4HPA7|MD10B_ARATH Mediator of RNA polymerase II transcription subunit 10b; TrEMBL-Plants: tr|C6TKB8|C6TKB8_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0374100 | 4 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR13345:SF8 | PANTHER | 1 | 20.00 |