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IPR019538

Source: InterPro

Description

IPR019538 is a 26S proteasome non-ATPase regulatory subunit 5.

<p>The 26S proteasome is an enzymatic complex that degrades ubiquitinated proteins in eukaryotic cells. 26S proteasome non-ATPase regulatory subunit 5 (PSMD5) is one of a number of chaperones that are involved in the assembly of the proteasome. The chaperones dissociate before 26S proteasome formation is complete [[cite:PUB00055592]].</p> <p>TNF-alpha/NFkB inhibits 26S proteasome assembly via abnormal expression of PSMD5, establishing a link between inflammation and chronic neurodegenerative diseases with altered ubiquitin-proteasome system function [[cite:PUB00072163]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0043248
Biological process Proteasome assembly The aggregation, arrangement and bonding together of a mature, active proteasome complex.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj3g3v0429130.1
– 26S proteasome non-ATPase regulatory subunit [Medicago truncatula] gi|357516527|ref|XP_003628552.1|
Domains
7
LotjaGi3g1v0045000.1
– ARM repeat superfamily protein; TAIR: AT3G15180.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q0P5A6|PSMD5_BOVIN 26S proteasome non-ATPase regulatory subunit 5; TrEMBL-Plants: tr|I1KDR0|I1KDR0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0045000
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF48371 SUPERFAMILY 1 50.00