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IPR019771 is a F-actin capping protein, beta subunit, conserved site.
<p>The actin filament system, a prominent part of the cytoskeleton in eukaryotic cells, is both a static structure and a dynamic network that can undergo rearrangements: it is thought to be involved in processes such as cell movement and phagocytosis [[cite:PUB00002626]], as well as muscle contraction.</p> <p>The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike gelsolin (see [interpro:IPR007122]) and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta. Neither of the subunits shows sequence similarity to other filament-capping proteins [[cite:PUB00002626]].</p> <p>The beta-subunit is a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species [[cite:PUB00004059]]. The signature pattern in this entry is a conserved hexapeptide in the N-terminal region of the beta-subunit.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Actin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Cellular component | F-actin capping protein complex | A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. | ||
| Biological process | Actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable F-actin-capping protein subunit beta-like [Glycine max] gi|356535733|ref|XP_003536398.1| | 7 | ||
| – | F-actin capping protein beta subunit; TAIR: AT1G71790.1 Subunits of heterodimeric actin filament capping protein Capz superfamily; Swiss-Prot: sp|Q9M9G7|CAPZB_ARATH Probable F-actin-capping protein subunit beta; TrEMBL-Plants: tr|I3T7I6|I3T7I6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0284900 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF90096 | SUPERFAMILY | 1 | 50.00 |