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IPR001698 is a F-actin-capping protein subunit beta.
<p>The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) and thereby restricts its growth. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta. Neither of the subunits shows sequence similarity to other filament-capping proteins [[cite:PUB00002626]].</p> <p>This entry represents the beta subunit (CAPZB), which is a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species [[cite:PUB00004059]]. In Drosophila mutations in the alpha and beta subunits cause actin accumulation and subsequent retinal degeneration [[cite:PUB00071410]]. In humans CAPZB is part of the WASH complex that controls the fission of endosomes [[cite:PUB00054152]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | F-actin capping protein complex | A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. | ||
| Biological process | Barbed-end actin filament capping | The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable F-actin-capping protein subunit beta-like [Glycine max] gi|356535733|ref|XP_003536398.1| | 7 | ||
| – | F-actin capping protein beta subunit; TAIR: AT1G71790.1 Subunits of heterodimeric actin filament capping protein Capz superfamily; Swiss-Prot: sp|Q9M9G7|CAPZB_ARATH Probable F-actin-capping protein subunit beta; TrEMBL-Plants: tr|I3T7I6|I3T7I6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0284900 | 18 | ||
| – | F-actin capping protein beta subunit; TAIR: AT1G71790.1 Subunits of heterodimeric actin filament capping protein Capz superfamily; Swiss-Prot: sp|Q9M9G7|CAPZB_ARATH Probable F-actin-capping protein subunit beta; TrEMBL-Plants: tr|I3T7I6|I3T7I6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0284900 | 8 | ||
| – | F-actin capping protein beta subunit; TAIR: AT1G71790.1 Subunits of heterodimeric actin filament capping protein Capz superfamily; Swiss-Prot: sp|Q9M9G7|CAPZB_ARATH Probable F-actin-capping protein subunit beta; TrEMBL-Plants: tr|I3T7I6|I3T7I6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0284900 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF90096 | SUPERFAMILY | 1 | 25.00 |