Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR020550 is a Inositol monophosphatase, conserved site.
<p>This entry represents a conserved signature pattern found within the inositol monophosphatase family of proteins. It is suggested [[cite:PUB00001628]] that these proteins may act by enhancing the synthesis or degradation of phosphorylated messenger molecules.</p> <p>It has been shown that several proteins share two sequence motifs [[cite:PUB00001628]]. Two of these proteins, vertebrate and plant inositol monophosphatase ([ec:3.1.3.25]), and vertebrate inositol polyphosphate 1-phosphatase ([ec:3.1.3.57]), are enzymes of the inositol phosphate second messenger signalling pathway, and share similar enzyme activity. Both enzymes exhibit an absolute requirement for metal ions (Mg2 is preferred), and their amino acid sequences contain a number of conserved motifs, which are also shared by several other proteins related to MPTASE (including products of fungal QaX and qutG, bacterial suhB and cysQ, and yeast hal2) [[cite:PUB00004864]]. The function of the other proteins is not yet clear, but it is suggested that they may act by enhancing the synthesis or degradation of phosphorylated messenger molecules [[cite:PUB00001628]].</p> <p>Structural analysis of these proteins has revealed a common core of 155 residues, which includes residues essential for metal binding and catalysis. An interesting property of the enzymes of this family is their sensitivity to Li+. The targets and mechanism of action of Li+ are unknown, but overactive inositol phosphate signalling may account for symptoms of manic depression [[cite:PUB00000822]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Phosphatidylinositol phosphorylation | The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: PAP-specific phosphatase HAL2-like [Glycine max] gi|356514784|ref|XP_003526083.1| | 14 | ||
| – | PREDICTED: PAP-specific phosphatase HAL2-like [Glycine max] gi|356545365|ref|XP_003541114.1| | 8 | ||
| – | PREDICTED: phosphatase IMPL1, chloroplastic-like [Glycine max] gi|356516969|ref|XP_003527163.1| | 12 | ||
| – | PREDICTED: PAP-specific phosphatase HAL2-like [Glycine max] gi|356549397|ref|XP_003543080.1| | 8 | ||
| – | PREDICTED: PAP-specific phosphatase HAL2-like [Cicer arietinum] gi|502142507|ref|XP_004504991.1| | 13 | ||
| – | Inositol monophosphatase [Phaseolus vulgaris] gi|227270347|emb|CAX94844.1| | 16 | ||
| – | 3(2),5-bisphosphate nucleotidase HAL2; TAIR: AT5G54390.1 HAL2-like protein; Swiss-Prot: sp|Q38945|DPNPH_ARATH PAP-specific phosphatase HAL2-like; TrEMBL-Plants: tr|A0A151TPN4|A0A151TPN4_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0321500 | 14 | ||
| – | 3'(2'),5'-bisphosphate nucleotidase 1; TAIR: AT5G63980.1 SAL1 phosphatase-like protein; Swiss-Prot: sp|Q42546|DPNP1_ARATH SAL1 phosphatase; TrEMBL-Plants: tr|A0A0B2R1H5|A0A0B2R1H5_GLYSO SAL1 phosphatase; Found in the gene: LotjaGi4g1v0021400 | 21 | ||
| – | 3'(2'),5'-bisphosphate nucleotidase 1; TAIR: AT5G63980.1 SAL1 phosphatase-like protein; Swiss-Prot: sp|Q42546|DPNP1_ARATH SAL1 phosphatase; TrEMBL-Plants: tr|A0A0B2R1H5|A0A0B2R1H5_GLYSO SAL1 phosphatase; Found in the gene: LotjaGi4g1v0021400 | 21 | ||
| – | 3'(2'),5'-bisphosphate nucleotidase 1; TAIR: AT5G63980.1 SAL1 phosphatase-like protein; Swiss-Prot: sp|Q42546|DPNP1_ARATH SAL1 phosphatase; TrEMBL-Plants: tr|A0A0B2R1H5|A0A0B2R1H5_GLYSO SAL1 phosphatase; Found in the gene: LotjaGi4g1v0021400 | 15 | ||
| – | 3(2),5-bisphosphate nucleotidase HAL2; TAIR: AT5G54390.1 HAL2-like protein; Swiss-Prot: sp|Q38945|DPNPH_ARATH PAP-specific phosphatase HAL2-like; TrEMBL-Plants: tr|I3S1P4|I3S1P4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0050900 | 13 | ||
| – | 3(2),5-bisphosphate nucleotidase HAL2; TAIR: AT5G54390.1 HAL2-like protein; Swiss-Prot: sp|Q38945|DPNPH_ARATH PAP-specific phosphatase HAL2-like; TrEMBL-Plants: tr|I3S1P4|I3S1P4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0051100 | 13 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT1G31190.1 myo-inositol monophosphatase like 1; Swiss-Prot: sp|Q94F00|IMPL1_ARATH Phosphatase IMPL1, chloroplastic; TrEMBL-Plants: tr|I3RZN3|I3RZN3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0021500 | 14 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT1G31190.1 myo-inositol monophosphatase like 1; Swiss-Prot: sp|Q94F00|IMPL1_ARATH Phosphatase IMPL1, chloroplastic; TrEMBL-Plants: tr|I3RZN3|I3RZN3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0021500 | 14 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT1G31190.1 myo-inositol monophosphatase like 1; Swiss-Prot: sp|Q94F00|IMPL1_ARATH Phosphatase IMPL1, chloroplastic; TrEMBL-Plants: tr|I3RZN3|I3RZN3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0021500 | 14 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT1G31190.1 myo-inositol monophosphatase like 1; Swiss-Prot: sp|Q94F00|IMPL1_ARATH Phosphatase IMPL1, chloroplastic; TrEMBL-Plants: tr|I3RZN3|I3RZN3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0021500 | 14 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT3G02870.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P54928|IMP3_SOLLC Inositol monophosphatase 3; TrEMBL-Plants: tr|I3S8Q4|I3S8Q4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0286000 | 16 | ||
| – | 3(2),5-bisphosphate nucleotidase HAL2; TAIR: AT5G54390.1 HAL2-like protein; Swiss-Prot: sp|Q38945|DPNPH_ARATH PAP-specific phosphatase HAL2-like; TrEMBL-Plants: tr|A0A0R0G583|A0A0R0G583_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0337300 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01517 | CDD | 1 | 5.56 |