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IPR020552 is a Inositol monophosphatase, lithium-sensitive.
<p>It has been shown that several proteins share two sequence motifs [[cite:PUB00001628]]. Two of these proteins, vertebrate and plant inositol monophosphatase ([ec:3.1.3.25]), and vertebrate inositol polyphosphate 1-phosphatase ([ec:3.1.3.57]), are enzymes of the inositol phosphate second messenger signalling pathway, and share similar enzyme activity. Both enzymes exhibit an absolute requirement for metal ions (Mg2 is preferred), and their amino acid sequences contain a number of conserved motifs, which are also shared by several other proteins related to MPTASE (including products of fungal QaX and qutG, bacterial suhB and cysQ, and yeast hal2) [[cite:PUB00004864]]. The function of the other proteins is not yet clear, but it is suggested that they may act by enhancing the synthesis or degradation of phosphorylated messenger molecules [[cite:PUB00001628]].</p> <p>Structural analysis of these proteins has revealed a common core of 155 residues, which includes residues essential for metal binding and catalysis. An interesting property of the enzymes of this family is their sensitivity to Li+. The targets and mechanism of action of Li+ are unknown, but overactive inositol phosphate signalling may account for symptoms of manic depression [[cite:PUB00000822]].</p> <p>An interesting property of the enzymes of this family is their sensitivity to Li+ at levels achieved in patients undergoing therapy for manic depression. The targets and mechanism of action of Li+ are unknown, but overactive inositol phosphate signalling may account for symptoms of the disease [[cite:PUB00000822], [cite:PUB00032773]]. It has been proposed that these Li+-sensitive proteins could represent targets for Li+ in manic depressive disease [[cite:PUB00004864], [cite:PUB00032773], [cite:PUB00046132]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Phosphatidylinositol phosphorylation | The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Inositol monophosphatase [Phaseolus vulgaris] gi|227270347|emb|CAX94844.1| | 14 | ||
| – | Inositol monophosphatase [Phaseolus vulgaris] gi|227270347|emb|CAX94844.1| | 16 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT3G02870.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P54928|IMP3_SOLLC Inositol monophosphatase 3; TrEMBL-Plants: tr|I3S8Q4|I3S8Q4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0286000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01639 | CDD | 1 | 33.33 |