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IPR033942 is a Inositol monophosphatase.
<p>This entry includes inositol monophosphatase (IMPase) and related proteins which are a family of Mg<sup>++</sup>dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled into inositol lipids; in eukaryotes IMPase plays a vital role in intracellular signaling [[cite:PUB00081816]]. IMPase is one of the proposed targets of Li<sup>+</sup>therapy in manic-depressive illness [[cite:PUB00004762], [cite:PUB00081817]]. This family contains some bacterial members of the inositol monophosphatase family classified as SuhB-like. E. coli SuhB has been suggested to participate in posstranscriptional control of gene expression, and its inositol monophosphatase activity doesn't appear to be sufficient for its cellular function. It has been proposed, that SuhB plays a role in the biosynthesis of phosphatidylinositol in mycobacteria [[cite:PUB00053644]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Inositol monophosphate 1-phosphatase activity | Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. | ||
| Biological process | Inositol phosphate dephosphorylation | The process of removing a phosphate group from any mono- or polyphosphorylated inositol. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: phosphatase IMPL1, chloroplastic-like [Glycine max] gi|356516969|ref|XP_003527163.1| | 12 | ||
| – | Inositol monophosphatase [Phaseolus vulgaris] gi|227270347|emb|CAX94844.1| | 14 | ||
| – | Inositol monophosphatase [Phaseolus vulgaris] gi|227270347|emb|CAX94844.1| | 16 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT1G31190.1 myo-inositol monophosphatase like 1; Swiss-Prot: sp|Q94F00|IMPL1_ARATH Phosphatase IMPL1, chloroplastic; TrEMBL-Plants: tr|I3RZN3|I3RZN3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0021500 | 14 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT1G31190.1 myo-inositol monophosphatase like 1; Swiss-Prot: sp|Q94F00|IMPL1_ARATH Phosphatase IMPL1, chloroplastic; TrEMBL-Plants: tr|I3RZN3|I3RZN3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0021500 | 14 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT1G31190.1 myo-inositol monophosphatase like 1; Swiss-Prot: sp|Q94F00|IMPL1_ARATH Phosphatase IMPL1, chloroplastic; TrEMBL-Plants: tr|I3RZN3|I3RZN3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0021500 | 14 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT1G31190.1 myo-inositol monophosphatase like 1; Swiss-Prot: sp|Q94F00|IMPL1_ARATH Phosphatase IMPL1, chloroplastic; TrEMBL-Plants: tr|I3RZN3|I3RZN3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0021500 | 14 | ||
| – | Inositol-1-monophosphatase family protein; TAIR: AT3G02870.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P54928|IMP3_SOLLC Inositol monophosphatase 3; TrEMBL-Plants: tr|I3S8Q4|I3S8Q4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0286000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01639 | CDD | 1 | 12.50 |