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IPR020867 is a Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site.
<p>Enzymes that participate in the transfer of one-carbon units require the coenzyme tetrahydrofolate (THF). Various reactions generate one-carbon derivatives of THF, which can be interconverted between different oxidation states by methylene-THF dehydrogenase ([ec:1.5.1.5]), methenyl-THF cyclohydrolase ([ec:3.5.4.9]) and formyl-THF synthetase ([ec:6.3.4.3]) [[cite:PUB00000304], [cite:PUB00000651]]. The dehydrogenase and cyclohydrolase activities are expressed by a variety of multifunctional enzymes, including the tri-functional eukaryotic C1-tetrahydrofolate synthase [[cite:PUB00000304]]; a bifunctional eukaryotic mitochondrial protein; and the bifunctional Escherichia coli folD protein [[cite:PUB00000304], [cite:PUB00000651]]. Methylene-tetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclo-hydrolase share an overlapping active site [[cite:PUB00000304]], and as such are usually located together in proteins, acting in tandem on the carbon-nitrogen bonds of substrates other than peptide bonds.</p> <p>The sequence of the dehydrogenase/cyclohydrolase domain is highly conserved in all forms of the enzyme. This entry contains two conserved signature patterns; the first one is located in the N-terminal part of these enzymes and contains three acidic residues. The second pattern is a highly conserved sequence of 9 amino acids, which is located in the C-terminal section.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: bifunctional protein FolD-like [Cicer arietinum] gi|502105032|ref|XP_004492706.1| | 9 | ||
| – | PREDICTED: bifunctional protein FolD-like [Cicer arietinum] gi|502105032|ref|XP_004492706.1| | 18 | ||
| – | 5,10-methylenetetrahydrofolate dehydrogenase-5,10-methenyltetrahydrofolate cyclohydrolase [Pisum sativum] gi|4103987|gb|AAD01907.1| | 18 | ||
| – | PREDICTED: bifunctional protein FolD-like [Glycine max] gi|356505416|ref|XP_003521487.1| | 17 | ||
| – | Bifunctional protein FolD; TAIR: AT4G00620.1 Amino acid dehydrogenase family protein; Swiss-Prot: sp|O65271|FOLD4_ARATH Bifunctional protein FolD 4, chloroplastic; TrEMBL-Plants: tr|Q2PES9|Q2PES9_TRIPR Putative tetrahydrofolate synthase; Found in the gene: LotjaGi1g1v0472300 | 24 | ||
| – | Bifunctional protein FolD; TAIR: AT4G00620.1 Amino acid dehydrogenase family protein; Swiss-Prot: sp|O65271|FOLD4_ARATH Bifunctional protein FolD 4, chloroplastic; TrEMBL-Plants: tr|A0A0B2R716|A0A0B2R716_GLYSO Bifunctional protein FolD; Found in the gene: LotjaGi1g1v0472300 | 18 | ||
| – | Bifunctional protein FolD; TAIR: AT4G00620.1 Amino acid dehydrogenase family protein; Swiss-Prot: sp|O65271|FOLD4_ARATH Bifunctional protein FolD 4, chloroplastic; TrEMBL-Plants: tr|A0A0B2R716|A0A0B2R716_GLYSO Bifunctional protein FolD; Found in the gene: LotjaGi1g1v0472300 | 18 | ||
| – | Bifunctional protein FolD; TAIR: AT3G12290.1 Amino acid dehydrogenase family protein; Swiss-Prot: sp|Q9LHH7|FOLD2_ARATH Bifunctional protein FolD 2; TrEMBL-Plants: tr|A0A0B2R2C7|A0A0B2R2C7_GLYSO C-1-tetrahydrofolate synthase, cytoplasmic; Found in the gene: LotjaGi1g1v0766400 | 18 | ||
| – | Bifunctional protein FolD; TAIR: AT2G38660.1 Amino acid dehydrogenase family protein; Swiss-Prot: sp|A2RVV7|FOLD1_ARATH Bifunctional protein FolD 1, mitochondrial; TrEMBL-Plants: tr|G7I8G5|G7I8G5_MEDTR Methylenetetrahydrofolate dehydrogenase; Found in the gene: LotjaGi3g1v0053700 | 17 | ||
| – | Bifunctional protein FolD; TAIR: AT2G38660.1 Amino acid dehydrogenase family protein; Swiss-Prot: sp|A2RVV7|FOLD1_ARATH Bifunctional protein FolD 1, mitochondrial; TrEMBL-Plants: tr|G7I8G5|G7I8G5_MEDTR Methylenetetrahydrofolate dehydrogenase; Found in the gene: LotjaGi3g1v0053700 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01080 | CDD | 1 | 10.00 |