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IPR021181 is a Mitochondrial Rho GTPase.
<p>Mitochondrial Rho (Miro) proteins are aberrant members of the small GTPase superfamily found in most eukaryotes. Miro contains a transmembrane region located at the C terminus anchors the protein to the outer membrane of mitochondria, the GTPase domains and EF-hands located in the cytoplasm. Miro and its cytoplasmic binding partner Milton/TRAK link mitochondria to kinesin and dynein molecular motors in various cell types [[cite:PUB00085980]]. Mammals have two Miro orthologs , Miro1 and Miro2. They mediate mitochondrial trafficking in neurons by linking mitochondria to kinesin and dynein motor proteins for their transport in axons and dendrites [[cite:PUB00085981], [cite:PUB00085982]]. Yeasts have one Miro homologue, known as Gem1, which is part of the ERMES complex that links the ER to mitochondria [[cite:PUB00085983]]. Interestingly, ERMES is absent in metazoa [[cite:PUB00085984]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + phosphate. | ||
| Molecular function | Calcium ion binding | Interacting selectively and non-covalently with calcium ions (Ca2+). | ||
| Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. | ||
| Biological process | Mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. | ||
| Cellular component | Integral component of mitochondrial outer membrane | The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: mitochondrial Rho GTPase 1-like [Glycine max] gi|356576775|ref|XP_003556505.1| | 30 | ||
| – | Mitochondrial Rho GTPase; TAIR: AT3G63150.1 MIRO-related GTP-ase 2; Swiss-Prot: sp|F4J0W4|MIRO2_ARATH Mitochondrial Rho GTPase 2; TrEMBL-Plants: tr|I1N9H1|I1N9H1_SOYBN Mitochondrial Rho GTPase; Found in the gene: LotjaGi1g1v0728100 | 29 | ||
| – | Mitochondrial Rho GTPase; TAIR: AT3G63150.1 MIRO-related GTP-ase 2; Swiss-Prot: sp|F4J0W4|MIRO2_ARATH Mitochondrial Rho GTPase 2; TrEMBL-Plants: tr|I1L835|I1L835_SOYBN Mitochondrial Rho GTPase; Found in the gene: LotjaGi5g1v0166400 | 28 | ||
| – | Mitochondrial Rho GTPase; TAIR: AT5G27540.1 MIRO-related GTP-ase 1; Swiss-Prot: sp|Q8RXF8|MIRO1_ARATH Mitochondrial Rho GTPase 1; TrEMBL-Plants: tr|A0A1J7FS16|A0A1J7FS16_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0220400 | 30 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01892 | CDD | 1 | 25.00 |