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IPR021910

Source: InterPro

Description

IPR021910 is a NGX6/PGAP6/MYMK.

<p>Proteins in this family include PGAP6 (also known as TMEM8A), NGX6 (also known as TMEM8B) and myomaker (also known as TMEM8C). TMEM8C is embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C-terminal tail. It is essential for myoblast fusion and sufficient to promote fusion of fibroblasts with muscle cells [[cite:PUB00086874]]. TMEM8A and TMEM8B has no fusogenic activity. TMEM8A is a GPI-specific phospholipase A2 involved in Nodal signaling modulation through CRIPTO shedding [[cite:PUB00086875]]. TMEM8B plays a role in cell adhesion modulation in nasopharyngeal carcinoma cells [[cite:PUB00086876]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016021
Cellular component Integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj1g3v2713920.1
– Transmembrane protein 8B [Medicago truncatula] gi|357504417|ref|XP_003622497.1|
Domains
17
LotjaGi3g1v0385400.1
– Transmembrane protein 8B; TAIR: AT2G46060.1 transmembrane protein-like protein; Swiss-Prot: sp|A6NDV4|TMM8B_HUMAN Transmembrane protein 8B; TrEMBL-Plants: tr|A0A151UCT6|A0A151UCT6_CAJCA Transmembrane protein 8B; Found in the gene: LotjaGi3g1v0385400
Domains
16
LotjaGi3g1v0385400.2
– Transmembrane protein 8B; TAIR: AT2G46060.1 transmembrane protein-like protein; Swiss-Prot: sp|A6NDV4|TMM8B_HUMAN Transmembrane protein 8B; TrEMBL-Plants: tr|A0A151UCT6|A0A151UCT6_CAJCA Transmembrane protein 8B; Found in the gene: LotjaGi3g1v0385400
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 33.33