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IPR022170 is a E3 Ubiquitin ligase MUL1-like.
<p>This domain is found in mitochondrial ubiquitin ligase activator of NFKB 1 (MULAN, also known as MUL1) from animals and ubiquitin E3 Ligase SP1/SP2/SPL1/SPL2 from Arabidopsis.</p> <p>MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial membrane with its RING finger domain facing the cytoplasm. Mul1 functions as a ubiquitin ligase to ubiquitinate molecules such as mitofusin2 (Mfn2), Akt, p53 and ULK1, through its RING finger domain, leading to proteins degradation. Moreover, Mul1 can also act as a small ubiquitin-like modifiers (SUMO) E3 ligase to sumoylate proteins such as dynamin-related protein 1 (Drp1), enhancing protein stabilization [[cite:PUB00093923]]. It plays a role in the control of mitochondrial morphology, promotes mitochondrial fragmentation and influences mitochondrial localisation [[cite:PUB00066813]]. When over-expressed in human cells, it activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis [[cite:PUB00066812]]. MUL1 has also been shown to regulate RIG-I mediated antiviral response [[cite:PUB00093921]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. | ||
| Biological process | Organelle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. | ||
| Biological process | Protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Baculoviral IAP repeat-containing protein [Medicago truncatula] gi|357514013|ref|XP_003627295.1| | 10 | ||
| – | PREDICTED: mitochondrial ubiquitin ligase activator of nfkb 1-like [Cicer arietinum] gi|502118042|ref|XP_004496072.1| | 20 | ||
| – | E3 Ubiquitin ligase; TAIR: AT1G54150.1 E3 Ubiquitin ligase family protein; Swiss-Prot: sp|Q9SYH3|SPL2P_ARATH E3 ubiquitin-protein ligase SPL2; TrEMBL-Plants: tr|A0A151S6Q2|A0A151S6Q2_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0414300 | 16 | ||
| – | E3 ubiquitin ligase-like protein; TAIR: AT1G63900.1 E3 Ubiquitin ligase family protein; Swiss-Prot: sp|Q8L7N4|SP1_ARATH E3 ubiquitin-protein ligase SP1; TrEMBL-Plants: tr|A0A0S3SS32|A0A0S3SS32_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0259100 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16515 | CDD | 1 | 25.00 |