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IPR022398 is a Peptidase S8, subtilisin, His-active site.
<p>This entry represents the conserved sequence around the His active site of Subtilisin-like proteases.</p> <p>Subtilases [[cite:PUB00004957]] are an extensive family of serine proteases belonging to the MEROPS peptidase family S8 (subtilisin, clan SB). Members of this family have a catalytic triad in the order Asp, His and Ser in the sequence, which is a different order to that of families S1, S9 and S10. The catalytic activity is provided by a charge relay system similar to that of the trypsin family of serine proteases but which evolved by independent convergent evolution. The sequence around the residues involved in the catalytic triad (Asp, Ser and His) are completely different from that of the analogous residues in the trypsin serine proteases and can be used as signatures specific to that category of proteases. If a protein includes at least two of the three active site signatures, the probability of it being a serine protease from the subtilase family is 100%.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Tripeptidyl-peptidase [Medicago truncatula] gi|357443997|ref|XP_003592276.1| | 18 | ||
| – | PREDICTED: cucumisin-like [Glycine max] gi|356499137|ref|XP_003518399.1| | 9 | ||
| – | PREDICTED: cucumisin-like [Glycine max] gi|356499137|ref|XP_003518399.1| | 9 | ||
| – | PREDICTED: cucumisin-like [Glycine max] gi|356499137|ref|XP_003518399.1| | 20 | ||
| – | PREDICTED: cucumisin-like [Glycine max] gi|356499137|ref|XP_003518399.1| | 19 | ||
| – | Subtilisin-like serine protease; TAIR: AT3G46850.1 Subtilase family protein; Swiss-Prot: sp|Q39547|CUCM1_CUCME Cucumisin; TrEMBL-Plants: tr|A0A0R0L1C5|A0A0R0L1C5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0049000 | 31 | ||
| – | Subtilisin-like serine protease; TAIR: AT3G46850.1 Subtilase family protein; Swiss-Prot: sp|Q39547|CUCM1_CUCME Cucumisin; TrEMBL-Plants: tr|A0A0B2PUU1|A0A0B2PUU1_GLYSO Cucumisin; Found in the gene: LotjaGi1g1v0084800 | 31 | ||
| – | Subtilisin-like serine protease; TAIR: AT3G46850.1 Subtilase family protein; Swiss-Prot: sp|Q39547|CUCM1_CUCME Cucumisin; TrEMBL-Plants: tr|A0A0R0L1C5|A0A0R0L1C5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0084800 | 31 | ||
| – | Subtilisin-like serine protease; TAIR: AT3G46850.1 Subtilase family protein; Swiss-Prot: sp|Q39547|CUCM1_CUCME Cucumisin; TrEMBL-Plants: tr|A0A0R0L1C5|A0A0R0L1C5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0084800 | 31 | ||
| – | Subtilisin-like protease 1; TAIR: AT5G19660.1 SITE-1 protease; Swiss-Prot: sp|Q0WUG6|SBT61_ARATH Subtilisin-like protease SBT6.1; TrEMBL-Plants: tr|V7C6B5|V7C6B5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0217500 | 25 | ||
| – | Subtilisin-like protease; TAIR: AT1G62340.1 PA-domain containing subtilase family protein; Swiss-Prot: sp|F4HYR6|SBT24_ARATH Subtilisin-like protease SBT2.4; TrEMBL-Plants: tr|A0A151SU26|A0A151SU26_CAJCA Subtilisin-like protease; Found in the gene: LotjaGi4g1v0011100 | 29 | ||
| – | Subtilisin-like protease; TAIR: AT1G62340.1 PA-domain containing subtilase family protein; Swiss-Prot: sp|F4HYR6|SBT24_ARATH Subtilisin-like protease SBT2.4; TrEMBL-Plants: tr|A0A151SU26|A0A151SU26_CAJCA Subtilisin-like protease; Found in the gene: LotjaGi4g1v0011100 | 29 | ||
| – | Subtilisin-like protease; TAIR: AT1G62340.1 PA-domain containing subtilase family protein; Swiss-Prot: sp|F4HYR6|SBT24_ARATH Subtilisin-like protease SBT2.4; TrEMBL-Plants: tr|A0A151SU26|A0A151SU26_CAJCA Subtilisin-like protease; Found in the gene: LotjaGi5g1v0172800 | 29 | ||
| – | Tripeptidyl-peptidase 2; TAIR: AT4G20850.1 tripeptidyl peptidase ii; Swiss-Prot: sp|F4JVN6|TPPII_ARATH Tripeptidyl-peptidase 2; TrEMBL-Plants: tr|I1LDQ6|I1LDQ6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0299800 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.14 |