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IPR034051 is a Tripeptidyl-peptidase II domain.
<p>Tripeptidyl-peptidase II (MEROPS identifier S08.090) is a member of the peptidase S8 or subtilase family. Tripeptidyl-peptidase II removes tripeptides from the free N terminus of oligopeptides as well as having endoproteolytic activity. Some tripeptidyl-peptidases have been shown to cleave tripeptides and small peptides, e.g. angiotensin II and glucagon, while others are believed to be involved in MHC I processing [[cite:PUB00082487]].</p> <p>Peptidases S8 (or subtilases serine endo- and exo-peptidase clan) have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values [[cite:PUB00004957], [cite:PUB00079863], [cite:PUB00000522], [cite:PUB00006225]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. | ||
| Molecular function | Tripeptidyl-peptidase activity | Catalysis of the release of an N-terminal tripeptide from a polypeptide. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Tripeptidyl-peptidase [Medicago truncatula] gi|357443997|ref|XP_003592276.1| | 18 | ||
| – | PREDICTED: tripeptidyl-peptidase 2-like isoform 1 [Glycine max] gi|356530860|ref|XP_003533997.1| | 16 | ||
| – | Tripeptidyl-peptidase 2; TAIR: AT4G20850.1 tripeptidyl peptidase ii; Swiss-Prot: sp|F4JVN6|TPPII_ARATH Tripeptidyl-peptidase 2; TrEMBL-Plants: tr|A0A151T4Q0|A0A151T4Q0_CAJCA Tripeptidyl-peptidase 2; Found in the gene: LotjaGi2g1v0141500 | 20 | ||
| – | Tripeptidyl-peptidase 2; TAIR: AT4G20850.1 tripeptidyl peptidase ii; Swiss-Prot: sp|F4JVN6|TPPII_ARATH Tripeptidyl-peptidase 2; TrEMBL-Plants: tr|A0A151T4Q0|A0A151T4Q0_CAJCA Tripeptidyl-peptidase 2; Found in the gene: LotjaGi2g1v0141500 | 20 | ||
| – | Tripeptidyl-peptidase 2; TAIR: AT4G20850.1 tripeptidyl peptidase ii; Swiss-Prot: sp|F4JVN6|TPPII_ARATH Tripeptidyl-peptidase 2; TrEMBL-Plants: tr|V7C4F5|V7C4F5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0141500 | 19 | ||
| – | Tripeptidyl-peptidase 2; TAIR: AT4G20850.1 tripeptidyl peptidase ii; Swiss-Prot: sp|F4JVN6|TPPII_ARATH Tripeptidyl-peptidase 2; TrEMBL-Plants: tr|A0A151T4Q0|A0A151T4Q0_CAJCA Tripeptidyl-peptidase 2; Found in the gene: LotjaGi2g1v0141500 | 19 | ||
| – | Tripeptidyl-peptidase 2; TAIR: AT4G20850.1 tripeptidyl peptidase ii; Swiss-Prot: sp|F4JVN6|TPPII_ARATH Tripeptidyl-peptidase 2; TrEMBL-Plants: tr|I1LDQ6|I1LDQ6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0299800 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |