Description

IPR022659 is a Proliferating cell nuclear antigen, PCNA, conserved site.

<p>Proliferating cell nuclear antigen (PCNA), or cyclin, is a non-histone acidic nuclear protein [[cite:PUB00001160]] that plays a key role in the control of eukaryotic DNA replication [[cite:PUB00001407]]. It acts as a co-factor for DNA polymerase delta, which is responsible for leading strand DNA replication [[cite:PUB00002545]]. The sequence of PCNA is well conserved between plants and animals, indicating a strong selective pressure for structure conservation, and suggesting that this type of DNA replication mechanism is conserved throughout eukaryotes [[cite:PUB00001388]]. In Saccharomyces cerevisiae (Baker's yeast), POL30, is associated with polymerase III, the yeast analog of polymerase delta.</p> <p>Homologues of PCNA have also been identified in the archaea (known as DNA polymerase sliding clamp) [[cite:PUB00059205], [cite:PUB00059204]] and in Paramecium bursaria Chlorella virus 1 (PBCV-1) and in nuclear polyhedrosis viruses.</p> <p>This entry represents two conserved regions located in the N-terminal section. The second one has been proposed to bind DNA.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 1

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: