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IPR022649 is a Proliferating cell nuclear antigen, PCNA, C-terminal.
<p>Proliferating cell nuclear antigen (PCNA), or cyclin, is a non-histone acidic nuclear protein [[cite:PUB00001160]] that plays a key role in the control of eukaryotic DNA replication [[cite:PUB00001407]]. It acts as a co-factor for DNA polymerase delta, which is responsible for leading strand DNA replication [[cite:PUB00002545]]. The sequence of PCNA is well conserved between plants and animals, indicating a strong selective pressure for structure conservation, and suggesting that this type of DNA replication mechanism is conserved throughout eukaryotes [[cite:PUB00001388]]. In Saccharomyces cerevisiae (Baker's yeast), POL30, is associated with polymerase III, the yeast analog of polymerase delta.</p> <p>Homologues of PCNA have also been identified in the archaea (known as DNA polymerase sliding clamp) [[cite:PUB00059205], [cite:PUB00059204]] and in Paramecium bursaria Chlorella virus 1 (PBCV-1) and in nuclear polyhedrosis viruses.</p> <p>The N-terminal and C-terminal domains of PCNA are topologically identical. Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA [[cite:PUB00015005]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Biological process | Regulation of DNA replication | Any process that modulates the frequency, rate or extent of DNA replication. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: proliferating cell nuclear antigen-like [Cicer arietinum] gi|502129176|ref|XP_004500211.1| | 11 | ||
| – | Proliferating cell nuclear antigen; TAIR: AT2G29570.1 proliferating cell nuclear antigen 2; Swiss-Prot: sp|O82134|PCNA_PEA Proliferating cell nuclear antigen; TrEMBL-Plants: tr|I3SD25|I3SD25_LOTJA Proliferating cell nuclear antigen; Found in the gene: LotjaGi6g1v0134900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00577 | CDD | 1 | 50.00 |