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IPR022694 is a 3-hydroxyacyl-CoA dehydrogenase.
<p>3-hydroxyacyl-CoA dehydrogenase ([ec:1.1.1.35]) (HCDH) [[cite:PUB00004646]] is an enzyme involved in fatty acid metabolism and catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. Most eukaryotic cells have two fatty-acid beta-oxidation systems, one located in mitochondria and the other in peroxisomes. In peroxisomes 3-hydroxyacyl-CoA dehydrogenase forms, with enoyl-CoA hydratase (ECH) and 3,2-trans-enoyl-CoA isomerase (ECI) a multifunctional enzyme where the N-terminal domain bears the hydratase/isomerase activities and the C-terminal domain the dehydrogenase activity. There are two mitochondrial enzymes: one which is monofunctional and the other which is, like its peroxisomal counterpart, multifunctional.</p> <p>In Escherichia coli (gene fadB) and Pseudomonas fragi (gene faoA) HCDH is part of a multifunctional enzyme which also contains an ECH/ECI domain as well as a 3-hydroxybutyryl-CoA epimerase domain [[cite:PUB00004380]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 3-hydroxyacyl-CoA dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). | ||
| Biological process | Fatty acid metabolic process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. | ||
| Molecular function | NAD+ binding | Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Peroxisomal 3-hydroxyacyl-CoA dehydrogenase-like protein [Glycine max] gi|351722947|ref|NP_001234958.1| | 16 | ||
| – | Fatty acid oxidation complex subunit alpha; TAIR: AT3G15290.1 3-hydroxyacyl-CoA dehydrogenase family protein; Swiss-Prot: sp|Q45223|HBD_BRADU 3-hydroxybutyryl-CoA dehydrogenase; TrEMBL-Plants: tr|I3SLI5|I3SLI5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0046500 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51735 | SUPERFAMILY | 1 | 50.00 |