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IPR006180 is a 3-hydroxyacyl-CoA dehydrogenase, conserved site.
<p>3-hydroxyacyl-CoA dehydrogenase ([ec:1.1.1.35]) (HCDH) [[cite:PUB00004646]] is an enzyme involved in fatty acid metabolism, it catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. Most eukaryotic cells have 2 fatty-acid beta-oxidation systems, one located in mitochondria and the other in peroxisomes. In peroxisomes 3-hydroxyacyl-CoA dehydrogenase forms, with enoyl-CoA hydratase (ECH) and 3,2-trans-enoyl-CoA isomerase (ECI) a multifunctional enzyme where the N-terminal domain bears the hydratase/isomerase activities and the C-terminal domain the dehydrogenase activity. There are two mitochondrial enzymes: one which is monofunctional and the other which is, like its peroxisomal counterpart, multifunctional.</p> <p>In Escherichia coli (gene fadB) and Pseudomonas fragi (gene faoA) HCDH is part of a multifunctional enzyme which also contains an ECH/ECI domain as well as a 3-hydroxybutyryl-CoA epimerase domain [[cite:PUB00004380]].</p> <p>The other proteins structurally related to HCDH are:</p> <ul><li>Bacterial 3-hydroxybutyryl-CoA dehydrogenase ([ec:1.1.1.157]) which reduces 3-hydroxybutanoyl-CoA to acetoacetyl-CoA [[cite:PUB00001734]].</li> <li>Eye lens protein lambda-crystallin [[cite:PUB00002465]], which is specific to lagomorphes (such as rabbit).</li></ul> <p>There are two major region of similarities in the sequences of proteins of the HCDH family, the first one located in the N-terminal, corresponds to the NAD-binding site, the second one is located in the centre of the sequence.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 3-hydroxyacyl-CoA dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). | ||
| Biological process | Fatty acid metabolic process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. | ||
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Peroxisomal 3-hydroxyacyl-CoA dehydrogenase-like protein [Glycine max] gi|351722947|ref|NP_001234958.1| | 16 | ||
| – | PREDICTED: peroxisomal fatty acid beta-oxidation multifunctional protein MFP2-like [Cicer arietinum] gi|502150946|ref|XP_004508202.1| | 24 | ||
| – | Fatty acid oxidation complex subunit alpha; TAIR: AT4G29010.1 Enoyl-CoA hydratase/isomerase family; Swiss-Prot: sp|Q9ZPI6|AIM1_ARATH Peroxisomal fatty acid beta-oxidation multifunctional protein AIM1; TrEMBL-Plants: tr|A0A151TIU1|A0A151TIU1_CAJCA Peroxisomal fatty acid beta-oxidation multifunctional protein; Found in the gene: LotjaGi2g1v0218000 | 25 | ||
| – | Fatty acid oxidation complex subunit alpha; TAIR: AT3G15290.1 3-hydroxyacyl-CoA dehydrogenase family protein; Swiss-Prot: sp|Q45223|HBD_BRADU 3-hydroxybutyryl-CoA dehydrogenase; TrEMBL-Plants: tr|I3SLI5|I3SLI5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0046500 | 17 | ||
| – | Fatty acid oxidation complex subunit alpha; TAIR: AT3G06860.1 multifunctional protein 2; Swiss-Prot: sp|Q39659|MFPA_CUCSA Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a; TrEMBL-Plants: tr|G7JLJ7|G7JLJ7_MEDTR Glyoxysomal fatty acid beta-oxidation MFP-A protein; Found in the gene: LotjaGi4g1v0339300 | 23 | ||
| – | Fatty acid oxidation complex subunit alpha; TAIR: AT3G06860.1 multifunctional protein 2; Swiss-Prot: sp|Q39659|MFPA_CUCSA Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a; TrEMBL-Plants: tr|A0A1J7GLM0|A0A1J7GLM0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0251400 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06558 | CDD | 1 | 16.67 |