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IPR022709 is a Protein SCAI.
<p>SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 [[cite:PUB00068364]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Transcription corepressor activity | A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A third class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators. | ||
| Biological process | Transcription, DNA-templated | The cellular synthesis of RNA on a template of DNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein SCAI-like [Cicer arietinum] gi|502140206|ref|XP_004504108.1| | 5 | ||
| – | PREDICTED: protein SCAI homolog [Glycine max] gi|356512676|ref|XP_003525043.1| | 5 | ||
| – | PREDICTED: protein SCAI-like [Glycine max] gi|356504470|ref|XP_003521019.1| | 3 | ||
| – | Protein SCAI; TAIR: AT3G03570.1 signal transducer, putative (DUF3550/UPF0682); Swiss-Prot: sp|Q8N9R8|SCAI_HUMAN Protein SCAI; TrEMBL-Plants: tr|I3T0M2|I3T0M2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0075200 | 4 | ||
| – | Protein SCAI; TAIR: AT3G03570.1 signal transducer, putative (DUF3550/UPF0682); Swiss-Prot: sp|Q8C8N2|SCAI_MOUSE Protein SCAI; TrEMBL-Plants: tr|I3T0M2|I3T0M2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0075200 | 4 | ||
| – | Protein SCAI; TAIR: AT4G40050.1 signal transducer, putative (DUF3550/UPF0682); Swiss-Prot: sp|Q8N9R8|SCAI_HUMAN Protein SCAI; TrEMBL-Plants: tr|A0A151S3H1|A0A151S3H1_CAJCA Protein SCAI; Found in the gene: LotjaGi4g1v0394900 | 5 | ||
| – | Protein SCAI; TAIR: AT4G40050.1 signal transducer, putative (DUF3550/UPF0682); Swiss-Prot: sp|Q8N9R8|SCAI_HUMAN Protein SCAI; TrEMBL-Plants: tr|A0A151S3H1|A0A151S3H1_CAJCA Protein SCAI; Found in the gene: LotjaGi4g1v0394900 | 5 | ||
| – | Protein SCAI; TAIR: AT4G40050.1 signal transducer, putative (DUF3550/UPF0682); Swiss-Prot: sp|Q8N9R8|SCAI_HUMAN Protein SCAI; TrEMBL-Plants: tr|A0A151S3H1|A0A151S3H1_CAJCA Protein SCAI; Found in the gene: LotjaGi4g1v0394900 | 4 | ||
| – | Protein SCAI; TAIR: AT4G40050.1 signal transducer, putative (DUF3550/UPF0682); Swiss-Prot: sp|Q8N9R8|SCAI_HUMAN Protein SCAI; TrEMBL-Plants: tr|A0A151S3H1|A0A151S3H1_CAJCA Protein SCAI; Found in the gene: LotjaGi4g1v0394900 | 5 | ||
| – | Protein SCAI; TAIR: AT4G40050.2 signal transducer, putative (DUF3550/UPF0682); Swiss-Prot: sp|Q8N9R8|SCAI_HUMAN Protein SCAI; TrEMBL-Plants: tr|A0A151S3H1|A0A151S3H1_CAJCA Protein SCAI; Found in the gene: LotjaGi4g1v0394900 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |