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IPR022776 is a TRM13/UPF0224 family, U11-48K-like CHHC zinc finger domain.
<p>This zinc binding domain [[cite:PUB00053822]] has four conserved zinc chelating residues in a CHHC pattern and is known as the CHHC U11-48K-type zinc finger.</p> <p>The CHHC U11-48K-type zinc finger is found only in eukaryotes. It has been identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors (GTSF). The CHHC U11-48K-type zinc finger (~30 residues) is present in a single copy in U11-48k AND TRM13, whereas GTSF contains two repeats separated by a short linker. The CHHC U11-48K-type zinc finger may function as a RNA recognition and binding module [[cite:PUB00053822], [cite:PUB00059781]].</p> <p>The CHHC U11-48K-type zinc finger contains four invariant Cys and His residues with a consensus sequence of C-x(5,7)-H-x(7,9)-H-x(3,4)-C. It stochiometrically binds zinc ions in a one-to-one ratio. The structure of the CHHC U11-48K-type zinc finger consists of a β hairpin followed by a helix. the zinc ion is coordinated by Cys and His residues from the β hairpin and by His and Cys residues from the helix, respectively. The helical region has an α-helical conformation that is interrupted in the middle by a single pi-helical turn [[cite:PUB00059781]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | TRNA:m(4)X modification enzyme TRM13-like protein; TAIR: AT4G01880.1 methyltransferase; Swiss-Prot: sp|Q9NUP7|TRM13_HUMAN tRNA:m(4)X modification enzyme TRM13 homolog; TrEMBL-Plants: tr|A0A151QXE9|A0A151QXE9_CAJCA tRNA guanosine-2'-O-methyltransferase TRM13 isogeny; Found in the gene: LotjaGi2g1v0071700 | 14 | ||
| – | U11/U12 small nuclear ribonucleoprotein 48 kDa protein; TAIR: AT3G04160.1 U11/U12 small nuclear ribonucleoprotein; Swiss-Prot: sp|Q9M8X2|U1148_ARATH U11/U12 small nuclear ribonucleoprotein 48 kDa protein; TrEMBL-Plants: tr|K7LJW1|K7LJW1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0098700 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |