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IPR022894

Source: InterPro

Description

IPR022894 is a Oligoribonuclease.

<p>Oligoribonuclease (Orn) is a DEDDh-type DnaQ-like 3'-5' exoribonuclease that is responsible for degrading small oligoribonucleotides to mononucleotides. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Orn is essential for Escherichia coli survival [[cite:PUB00040994]]. The human homologue, also called Sfn (small fragment nuclease), is able to hydrolyse short single-stranded RNA and DNA oligomers. It plays a role in cellular nucleotide recycling [[cite:PUB00086001], [cite:PUB00086002]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000175
Molecular function 3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0055000.1
– Oligoribonuclease; TAIR: AT2G26970.1 Polynucleotidyl transferase, ribonuclease H-like superfamily protein; Swiss-Prot: sp|Q9ZVE0|ORN_ARATH Oligoribonuclease; TrEMBL-Plants: tr|A0A151U1P3|A0A151U1P3_CAJCA Oligoribonuclease; Found in the gene: LotjaGi1g1v0055000
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00