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IPR023160

Source: InterPro

Description

IPR023160 is a Ribonuclease HII, helix-loop-helix cap domain superfamily.

<p>This superfamily represents the helix-loop-helix cap domain of ribonuclease HII. This C-terminal domain forms a compact structure consisting of two α-helices: α8 and α9. Unlike the N-terminal domain, bacterial RNases HI do not possess this domain. In the full-length enzyme, the α9 helix is followed by 15 amino acid residues, of which conformation is likely to be flexible, as revealed from the susceptibility to trypsin digestion. It has been suggested that this domain confers substrate-specific binding capacity to the core nuclease architecture, thus accounting for the endonucleolytic specificity of the type 2 RNase H family members [[cite:PUB00021793]]. It also has been suggested that this domain to be involved in the interaction with the DNA/RNA hybrid [[cite:PUB00026076]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004523
Molecular function RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj5g3v2240790.1
– PREDICTED: ribonuclease H2 subunit A-like isoform X2 [Cicer arietinum] gi|502120984|ref|XP_004497148.1|
Domains
12
LotjaGi5g1v0344200.1
– Ribonuclease HII; TAIR: AT2G25100.1 Polynucleotidyl transferase, ribonuclease H-like superfamily protein; Swiss-Prot: sp|Q9SEZ6|RNH2A_ARATH Ribonuclease H2 subunit A; TrEMBL-Plants: tr|A0A072W210|A0A072W210_MEDTR Ribonuclease; Found in the gene: LotjaGi5g1v0344200
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00