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IPR023943 is a Enolase-phosphatase E1.
<p>This enzyme is the enolase-phosphatase of methionine salvage, a pathway that regenerates methionine from methylthioadenosine (MTA). Adenosylmethionine (AdoMet) is a donor of different moieties for various processes, including methylation reactions. Use of AdoMet for spermidine biosynthesis, which leads to polyamine biosynthesis, leaves MTA as a by-product that must be cleared. In Bacillus subtilis and related species, this single protein is replaced by separate enzymes with enolase and phosphatase activities.</p> <p>This entry also matches a number of probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 enzymes.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Magnesium ion binding | Interacting selectively and non-covalently with magnesium (Mg) ions. | ||
| Biological process | L-methionine salvage from methylthioadenosine | The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. | ||
| Molecular function | Acireductone synthase activity | Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1-like [Glycine max] gi|356544052|ref|XP_003540469.1| | 11 | ||
| – | PREDICTED: probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1-like isoform 1 [Glycine max] gi|356517132|ref|XP_003527244.1| | 22 | ||
| – | Methylthioribulose-1-phosphate dehydratase; TAIR: AT5G53850.2 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|B9N1F9|MTBC_POPTR Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; TrEMBL-Plants: tr|I1KDU3|I1KDU3_SOYBN Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; Found in the gene: LotjaGi3g1v0046900 | 28 | ||
| – | Enolase-phosphatase E1; TAIR: AT5G53850.2 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|B9N1F9|MTBC_POPTR Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; TrEMBL-Plants: tr|I3SC04|I3SC04_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0153500_LC | 12 | ||
| – | Enolase-phosphatase E1; TAIR: AT5G53850.2 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|B9N1F9|MTBC_POPTR Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; TrEMBL-Plants: tr|A0A151SVM5|A0A151SVM5_CAJCA Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; Found in the gene: LotjaGi3g1v0153500_LC | 16 | ||
| – | Enolase-phosphatase E1; TAIR: AT5G53850.2 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|B9N1F9|MTBC_POPTR Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; TrEMBL-Plants: tr|I3SC04|I3SC04_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0153500_LC | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR01691 | TIGRFAM | 1 | 16.67 |