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IPR024337 is a tRNA-splicing endonuclease, subunit Sen54.
<p>tRNA-splicing endonucleases ([ec:3.1.27.9]) catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini [[cite:PUB00054270], [cite:PUB00055529]]. The genes encoding these proteins are homologous in eukaryotes and archea. The eukaryotic tRNA-splicing endonucleases are heterotetrameric while the archaeal endonucleases can be split into homodimeric and homotetrameric subgroups.</p> <p>Sen54 is a non-catalytic subunit of the tRNA-splicing endonuclease complex. Defects in human Sen54 are a cause of pontocerebellar hypoplasia type 4 [[cite:PUB00056002]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: tRNA-splicing endonuclease subunit Sen54-like isoform X1 [Cicer arietinum] gi|502108421|ref|XP_004493467.1| | 4 | ||
– | PREDICTED: tRNA-splicing endonuclease subunit Sen54-like isoform X1 [Cicer arietinum] gi|502108421|ref|XP_004493467.1| | 4 | ||
– | PREDICTED: tRNA-splicing endonuclease subunit Sen54-like isoform X1 [Cicer arietinum] gi|502108421|ref|XP_004493467.1| | 4 | ||
– | TRNA-splicing endonuclease subunit Sen54; TAIR: AT3G57360.1 tRNA-splicing endonuclease subunit; Swiss-Prot: sp|Q8C2A2|SEN54_MOUSE tRNA-splicing endonuclease subunit Sen54; TrEMBL-Plants: tr|A0A151TTW2|A0A151TTW2_CAJCA tRNA-splicing endonuclease subunit Sen54; Found in the gene: LotjaGi1g1v0671100 | 2 | ||
– | TRNA-splicing endonuclease subunit; TAIR: AT3G57360.1 tRNA-splicing endonuclease subunit; Swiss-Prot: sp|Q7Z6J9|SEN54_HUMAN tRNA-splicing endonuclease subunit Sen54; TrEMBL-Plants: tr|A0A151TTW2|A0A151TTW2_CAJCA tRNA-splicing endonuclease subunit Sen54; Found in the gene: LotjaGi1g1v0671100 | 4 | ||
– | TRNA-splicing endonuclease subunit Sen54; TAIR: AT3G57360.1 tRNA-splicing endonuclease subunit; Swiss-Prot: sp|Q8C2A2|SEN54_MOUSE tRNA-splicing endonuclease subunit Sen54; TrEMBL-Plants: tr|A0A072TTP9|A0A072TTP9_MEDTR tRNA-splicing endonuclease subunit sen54 amino-terminal protein; Found in the gene: LotjaGi6g1v0202300 | 2 | ||
– | TRNA-splicing endonuclease subunit Sen54; TAIR: AT3G57360.1 tRNA-splicing endonuclease subunit; Swiss-Prot: sp|Q7Z6J9|SEN54_HUMAN tRNA-splicing endonuclease subunit Sen54; TrEMBL-Plants: tr|A0A072TTP9|A0A072TTP9_MEDTR tRNA-splicing endonuclease subunit sen54 amino-terminal protein; Found in the gene: LotjaGi6g1v0202300 | 4 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
PTHR21027 | PANTHER | 1 | 14.29 |