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IPR024372 is a Proteasome component Ecm29.
<p>The proteasome (or macropain) ([ec:3.4.25.1]) [[cite:PUB00000524], [cite:PUB00000148], [cite:PUB00004123], [cite:PUB00001329], [cite:PUB00005460]] is a multicatalytic proteinase complex in eukaryotes and archaea, and in some bacteria, that is involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway. In eukaryotes the 20S proteasome is composed of 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700kDa. Proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B). The proteasome consists of four stacked rings composed of α/β/β/α subunits. There are seven different alpha subunits and seven different beta subunits [[cite:PUB00030848]]. Three of the seven beta subunits are peptidases, each with a different specificity. Subunit beta1c (MEROPS identifier T01.010) has a preference for cleaving glutaminyl bonds ("peptidyl-glutamyl-like" or "caspase-like"), subunit beta2c (MEROPS identifier T01.011) has a preference for cleaving arginyl and lysyl bonds ("trypsin-like"), and subunit beta5c (MEROPS identifier T01.012) cleaves after hydrophobic amino acids ("chymotrypsin-like") [[cite:PUB00080992]]. The proteasome subunits are related to N-terminal nucleophile hydrolases, and the catalytic subunits have an N-terminal threonine nucleophile.</p> <p>Ecm29 is an adapter/scaffolding protein that tethers the proteasome core particle to the regulatory particle, stabilising the interaction between these two components [[cite:PUB00056021], [cite:PUB00056022], [cite:PUB00056023]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Proteasome assembly | The aggregation, arrangement and bonding together of a mature, active proteasome complex. | ||
| Molecular function | Molecular adaptor activity | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: proteasome-associated protein ECM29 homolog [Cicer arietinum] gi|502098370|ref|XP_004491219.1| | 8 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: proteasome-associated protein ECM29 homolog [Cicer arietinum] gi|502098370|ref|XP_004491219.1| | 8 | ||
| – | Proteasome-associated ECM29-like protein; TAIR: AT2G26780.2 ARM repeat superfamily protein; Swiss-Prot: sp|Q5VYK3|ECM29_HUMAN Proteasome-associated protein ECM29 homolog; TrEMBL-Plants: tr|G7KCU1|G7KCU1_MEDTR Proteasome-associated ECM29-like protein; Found in the gene: LotjaGi1g1v0052500 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48371 | SUPERFAMILY | 1 | 33.33 |