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IPR025304

Source: InterPro

Description

IPR025304 is a ALIX V-shaped domain.

<p>The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding. In ALIX, a component of the ESCRT pathway, this domain is central between an N-terminal Bro1 domain ([pfam:PF03097]) and a C-terminal proline-rich domain. The ALIX central domain is formed by two three-helix bundles disposed in a V shape [[cite:PUB00042168], [cite:PUB00042214]]. Retroviruses thus used this domain to hijack the ESCRT system of the cell [[cite:PUB00049203]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005515
Molecular function Protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
Lj0g3v0288119.1
– PREDICTED: ALG-2 interacting protein X-like [Glycine max] gi|356536236|ref|XP_003536645.1|
Domains
15
LotjaGi5g1v0332400.1
– ALG-2 interacting protein X; TAIR: AT1G15130.1 Endosomal targeting BRO1-like domain-containing protein; Swiss-Prot: sp|Q8T7K0|ALIX_DICDI ALG-2 interacting protein X; TrEMBL-Plants: tr|I1LEN7|I1LEN7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0332400
Domains
16
LotjaGi5g1v0332400.2
– ALG-2 interacting protein X; TAIR: AT1G15130.1 Endosomal targeting BRO1-like domain-containing protein; Swiss-Prot: sp|Q8T7K0|ALIX_DICDI ALG-2 interacting protein X; TrEMBL-Plants: tr|A0A0S3SM52|A0A0S3SM52_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0332400
Domains
14
LotjaGi5g1v0332400.3
– ALG-2 interacting protein X; TAIR: AT1G15130.1 Endosomal targeting BRO1-like domain-containing protein; Swiss-Prot: sp|Q8T7K0|ALIX_DICDI ALG-2 interacting protein X; TrEMBL-Plants: tr|I1LEN7|I1LEN7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0332400
Domains
16
LotjaGi5g1v0332400.4
– ALG-2 interacting protein X; TAIR: AT1G15130.1 Endosomal targeting BRO1-like domain-containing protein; Swiss-Prot: sp|Q8T7K0|ALIX_DICDI ALG-2 interacting protein X; TrEMBL-Plants: tr|I1LEN7|I1LEN7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0332400
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 20.00