Description

IPR025762 is a DFDF domain.

<p>Sm and Sm-like proteins of the RNA-binding Lsm (like Sm) domain family are found in all domains of life and are generally involved in important RNA- processing tasks. Lsm13-16 homologs share a domain organisation consisting of a divergent N-terminal Lsm domain and a central or C-terminal consensus motif DFDF-x(7)-F closely preceded and followed by further phenylalanines and charged aspartates/glutamates and arginines/lysines/histidines. The variable seven-residue tract of this consensus motif usually contains an asparagine at the third or fourth position except of one sequence where the asparagine is replaced by a glycine. In few other sequences, the DFDF box is replaced by a DYDF or EFDF box [[cite:PUB00044226]]. The DFDF domain is a heterodimerization domain, which adopts a helical conformation upon binding. It folds into two consecutive α helices that are preceded and connected by the FDF and a related FDK sequence [[cite:PUB00050094]].</p> <p>Two other strongly conserved FFD box and TFG box sequence motifs Y-x-K-x(3)- FFD-x-[IL]-S and [RKH]-x(2,5)-E-x(0-2)-[RK]-x(3,4)-[DE]-TFG contained in Lsm13-15, but not Lsm16, homologs succeed the DFDF-x(7)-F motif and are also predicted to be of helical nature [[cite:PUB00044226]].</p> <p>This entry represents the DFDF domain.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: