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IPR025852

Source: InterPro

Description

IPR025852 is a Ataxin 2, SM domain.

<p>This SM domain is found in Ataxin-2 [[cite:PUB00012814], [cite:PUB00066661]]. This domain has been shown to interact with RNA helicase DDX6 [[cite:PUB00065004]].</p> <p>Ataxin-2 has many functions, such as endocytic receptor cycling [[cite:PUB00077680]], translational regulation, embryonic development [[cite:PUB00077683]], energy metabolism and weight regulation [[cite:PUB00077684]]. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination [[cite:PUB00077681]]. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein [[cite:PUB00077682]]. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [[cite:PUB00095159]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 13

Transcript Name Description Predicted domains Domain count
Lj3g3v0338980.1
– Ataxin-2 [Medicago truncatula] gi|357454537|ref|XP_003597549.1|
Domains
9
Lj3g3v0338980.2
– Ataxin-2 [Medicago truncatula] gi|357454537|ref|XP_003597549.1|
Domains
9
Lj3g3v0338980.4
– Ataxin-2 [Medicago truncatula] gi|357454537|ref|XP_003597549.1|
Domains
9
Lj3g3v2655630.1
– Ataxin-2 [Medicago truncatula] gi|357454537|ref|XP_003597549.1|
Domains
11
Lj6g3v0920410.1
– AT4g26990/F10M23_330 [Arabidopsis lyrata subsp]. lyrata] gi|297799292|ref|XP_002867530.1|
Domains
5
LotjaGi3g1v0029400.1
– CTC-interacting domain 4; TAIR: AT1G54170.1 CTC-interacting domain 3; Swiss-Prot: sp|Q8L793|CID3_ARATH Polyadenylate-binding protein-interacting protein 3; TrEMBL-Plants: tr|I1M589|I1M589_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0029400
Domains
11
LotjaGi3g1v0029400.2
– CTC-interacting domain 4; TAIR: AT1G54170.1 CTC-interacting domain 3; Swiss-Prot: sp|Q8L793|CID3_ARATH Polyadenylate-binding protein-interacting protein 3; TrEMBL-Plants: tr|I1M589|I1M589_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0029400
Domains
11
LotjaGi3g1v0029400.3
– CTC-interacting domain 4; TAIR: AT1G54170.1 CTC-interacting domain 3; Swiss-Prot: sp|Q8L793|CID3_ARATH Polyadenylate-binding protein-interacting protein 3; TrEMBL-Plants: tr|I1M589|I1M589_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0029400
Domains
11
LotjaGi3g1v0029400.4
– CTC-interacting domain 4; TAIR: AT1G54170.1 CTC-interacting domain 3; Swiss-Prot: sp|Q8L793|CID3_ARATH Polyadenylate-binding protein-interacting protein 3; TrEMBL-Plants: tr|I1M589|I1M589_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0029400
Domains
11
LotjaGi3g1v0029400.5
– CTC-interacting domain 4; TAIR: AT1G54170.1 CTC-interacting domain 3; Swiss-Prot: sp|Q8L793|CID3_ARATH Polyadenylate-binding protein-interacting protein 3; TrEMBL-Plants: tr|I1M589|I1M589_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0029400
Domains
11
LotjaGi3g1v0029400.6
– CTC-interacting domain 4; TAIR: AT1G54170.1 CTC-interacting domain 3; Swiss-Prot: sp|Q8L793|CID3_ARATH Polyadenylate-binding protein-interacting protein 3; TrEMBL-Plants: tr|I1M589|I1M589_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0029400
Domains
11
LotjaGi3g1v0417300.1
– CTC-interacting domain 4; TAIR: AT3G14010.1 CTC-interacting domain 4; Swiss-Prot: sp|Q94AM9|CID4_ARATH Polyadenylate-binding protein-interacting protein 4; TrEMBL-Plants: tr|A0A072TMN5|A0A072TMN5_MEDTR CTC-interacting domain protein; Found in the gene: LotjaGi3g1v0417300
Domains
10
LotjaGi6g1v0167200.1
– Polyadenylate-binding protein-interacting protein 4; TAIR: AT5G54920.1 polyadenylate-binding protein interacting protein; Swiss-Prot: sp|Q94AM9|CID4_ARATH Polyadenylate-binding protein-interacting protein 4; TrEMBL-Plants: tr|K7MQZ4|K7MQZ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0167200
Domains
5

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 7.69