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IPR025927 is a KANL2-like, probable zinc-finger domain.
<p>This domain is found in the human KAT8 regulatory NSL complex subunit 2 (KANSL2) and related proteins including INO80 complex subunit D (INO80D) and Protein SUMV-1 from C. elegans. It contains six invariant cysteine and two histidines that define a C3HC3H conserved pattern and probably are involved in zinc coordination.</p> <p>KANSL2 is a non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at Lys-5 and Lys-8 (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation [[cite:PUB00060167], [cite:PUB00158874]]. KANSL2 protects the integrity of the NSL complex [[cite:PUB00160464]]. KANSL2 has a pair of this domain, the second of which was found to be essential to NSL complex function [[cite:PUB00160464]].</p> <p>INO80D is a member of the INO80 chromatin-modifying complex and has been shown to interact with the NSL complex [[cite:PUB00060167]].</p> <p>Protein SUMV-1 is a nuclear factor that influences the activity of genes involved in vulval development [[cite:PUB00075333]]. SUMV-1 physically interacts with SUMV-2 and both likely function together with MYS-2 in a nematode KAT8/MOF-like complex to antagonise the activity of the synMuv genes [[cite:PUB00075333]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: INO80 complex subunit D-like [Cicer arietinum] gi|502106996|ref|XP_004493123.1| | 4 | ||
| – | PREDICTED: INO80 complex subunit D-like [Fragaria vesca subsp]. vesca] gi|470124091|ref|XP_004298050.1| | 4 | ||
| – | INO80 complex subunit D; TAIR: AT2G31600.1 INO80 complex subunit D-like protein; Swiss-Prot: sp|Q54J07|IN80D_DICDI INO80 complex subunit D; TrEMBL-Plants: tr|A0A1J7IFN4|A0A1J7IFN4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0637800 | 5 | ||
| – | INO80 complex subunit D; TAIR: AT1G05860.1 INO80 complex subunit D-like protein; Swiss-Prot: sp|Q54J07|IN80D_DICDI INO80 complex subunit D; TrEMBL-Plants: tr|A0A067L341|A0A067L341_JATCU Uncharacterized protein; Found in the gene: LotjaGi5g1v0363400 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SignalP-noTM | SignalP_GRAM_NEGATIVE | 1 | 25.00 |