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IPR026000 is a Anaphase-promoting complex subunit 5 domain.
<p>This entry represents a domain found in Apc5 (anaphase-promoting complex subunit 5).</p> <p>Apc5 is a subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a multisubunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1. Tetratricopeptide repeat protein 19 is a mitochondrial protein required for formation of the mitochondrial complex III [[cite:PUB00066793]].</p> <p>Apc5, although it does not harbour a classical RNA binding domain, Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA. PABP was found to enhance IRES-mediated translation, whereas Apc5 over-expression counteracted this effect. In addition to its association with the APC/C complex, Apc5 binds much heavier complexes and co-sediments with the ribosomal fraction [[cite:PUB00059189], [cite:PUB00055977]]. The N terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC [[cite:PUB00059190]]. This region of the Apc5 member proteins carries a TPR-like motif.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: anaphase-promoting complex subunit 5-like [Glycine max] gi|356553615|ref|XP_003545150.1| | 8 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: anaphase-promoting complex subunit 5-like [Glycine max] gi|356553615|ref|XP_003545150.1| | 8 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: anaphase-promoting complex subunit 5-like [Glycine max] gi|356553615|ref|XP_003545150.1| | 4 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|V7B6H8|V7B6H8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0044200 | 6 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0044200 | 11 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0044200 | 13 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A151QXF2|A0A151QXF2_CAJCA Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900 | 9 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A151QXF2|A0A151QXF2_CAJCA Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900 | 9 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|V7B6H8|V7B6H8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0738900 | 9 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900 | 10 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|V7B6H8|V7B6H8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0738900 | 10 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 8.33 |