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IPR037679 is a Anaphase-promoting complex subunit 5.
<p>Apc5 is a subunit of the eukaryotic anaphase-promoting complex/cyclosome (APC/C) which is a multi-subunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1. Although Apc5 does not contain a classical RNA binding domain, it binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA [[cite:PUB00059189]].</p> <p>This entry also includes two Apc5 paralogues from C. elegans: such-1 and gfi-3. They are coexpressed in the germline but have nonoverlapping expression patterns in other tissues. They have a redundant function during the meiotic divisions [[cite:PUB00087469]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Anaphase-promoting complex | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|V7B6H8|V7B6H8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0044200 | 6 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0S3RJT4|A0A0S3RJT4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0044200 | 5 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0044200 | 11 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0044200 | 13 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A151QXF2|A0A151QXF2_CAJCA Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900 | 9 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A151QXF2|A0A151QXF2_CAJCA Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900 | 9 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|V7B6H8|V7B6H8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0738900 | 9 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900 | 10 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0S3RJT4|A0A0S3RJT4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0738900 | 9 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|V7B6H8|V7B6H8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0738900 | 10 | ||
| – | Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |