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IPR027032 is a Twinkle-like protein.
<p>Twinkle protein (T7-like mitochondrial DNA helicase) is a DNA helicase needed for mitochondrial DNA replication [[cite:PUB00062736]]. It catalyses the ATP-dependent unwinding of a DNA duplex with 5' to 3' directionality, and it needs a single-stranded 5'-DNA and a short 3'-tail to initiate unwinding [[cite:PUB00062734]]. In humans, mutations in TWINKLE cause autosomal dominant progressive external ophthalmoplegia, a human disorder associated with multiple deletions in the mitochondrial DNA [[cite:PUB00033779]]. Arabidopsis encodes a homologue to phage T7 gp4/Twinkle proteins that has both DNA primase and DNA helicase activities [[cite:PUB00070301]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Toprim domain-containing protein isoform 4 [Theobroma cacao] gi|508778400|gb|EOY25656.1| | 10 | ||
| – | PREDICTED: DNA primase/helicase-like [Cicer arietinum] gi|502163739|ref|XP_004512933.1| | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01029 | CDD | 1 | 50.00 |