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IPR027081

Source: InterPro

Description

IPR027081 is a CyclinH/Ccl1.

<p>Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [[cite:PUB00014103]], and regulate cyclin dependent kinases (CDKs).</p> <p>This entry includes cyclin-H from vertebrates, mcs2 from fission yeast and Ccl1 from budding yeasts. They are cyclins that play a role in cell cycle. They are also subunits forming the core-TFIIH basal transcription factor. Human cyclin-H regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex [[cite:PUB00069500]]. mcs2 posseses kinase activity that can be detected when myelin basic protein (MBP) is provided as an exogenous substrate [[cite:PUB00069499]]. Ccl1 is a regulatory component of the TFIIK complex, which is the protein kinase component of transcription factor IIH (TFIIH). TFIIH is essential for both basal and activated transcription and is involved in nucleotide excision repair (NER) of damaged DNA and in polymerase II transcription [[cite:PUB00062852]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006351
Biological process Transcription, DNA-templated The cellular synthesis of RNA on a template of DNA.
Subterm of
Part of
GO:0016538
Molecular function Cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
Subterm of
GO:0070985
Cellular component Transcription factor TFIIK complex A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin2p/CDK7.
Subterm of
Part of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
Lj0g3v0326469.1
– PREDICTED: cyclin-H1-1 isoform 1 [Glycine max] gi|356516489|ref|XP_003526926.1|
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00