Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

GO:0005675

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Transcription factor TFIIH holo complex
Full defintion A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.
Subterm of

Relationships

The relationship of GO:0005675 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0005675, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

  • Drag and drop nodes to manually position (i.e. fix) them
  • Double click on a node to unfix the node
  • Press Alt and double click to visit the page containing further details of a GO term
  • Right clicking on a node will reveal a context menu

Controls

Force layout

Every force layout is different—we have picked a set of parameters which suits most GO ancestor tree chart well. If you mess something up—don't worry: hitting the "reset view" button above will reset the chart to its default layout.

Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCkrc
PMID
Different forms of TFIIH for transcription and DNA repair: holo-TFIIH and a nucleotide excision repairosome.Svejstrup JQ, Wang Z, Feaver WJ, Wu X, Bushnell DA, Donahue TF, Friedberg EC, Kornberg RD
Cell. 1995 Jan 13; 80 (1): 21–8.PMID: 7813015

Yeast TFIIH that is active in transcription can be dissociated into three components: a 5-subunit core, the SSL2 gene product, and a complex of 47 kDa, 45 kDa, and 33 kDa polypeptides that possesses protein kinase activity directed towards the C-terminal repeat domain of RNA polymerase II. These three components can reconstitute fully functional TFIIH, and all three are required for transcription in vitro. By contrast, TFIIH that is highly active in nucleotide excision repair (NER) lacks the kinase complex and instead contains the products of all other genes known to be required for NER in yeast: RAD1, RAD2, RAD4, RAD10, and RAD14. This repairosome is not active in reconstituted transcription in vitro and is significantly more active than any of the constituent polypeptides in correcting defective repair in extracts from strains mutated in NER genes.

Associated Lotus transcripts 10

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0067129.1
– PREDICTED: pentatricopeptide repeat-containing protein At4g30825, chloroplastic-like [Glycine max] gi|356508382|ref|XP_003522936.1|
GO terms
4
Lj2g3v1022790.1
– CDK-activating kinase assembly factor MAT1 [Medicago truncatula] gi|357495969|ref|XP_003618273.1|
GO terms
4
Lj2g3v1022790.2
– CDK-activating kinase assembly factor MAT1 [Medicago truncatula] gi|357495969|ref|XP_003618273.1|
GO terms
4
Lj2g3v1106410.1
– CDK-activating kinase assembly factor MAT1 [Medicago truncatula] gi|357495969|ref|XP_003618273.1|
GO terms
4
LotjaGi2g1v0254400_LC.1
– CDK-activating kinase assembly factor; TAIR: AT4G30820.11 cyclin-dependent kinase-activating kinase assembly factor-related / CDK-activating kinase assembly factor-like protein; Swiss-Prot: sp|P51950|MAT1_MARGL CDK-activating kinase assembly factor MAT1; TrEMBL-Plants: tr|G7KI90|G7KI90_MEDTR CDK-activating kinase assembly factor MAT1, putative; Found in the gene: LotjaGi2g1v0254400_LC
GO terms
4
LotjaGi2g1v0254400_LC.2
– CDK-activating kinase assembly factor; TAIR: AT4G30820.1 cyclin-dependent kinase-activating kinase assembly factor-related / CDK-activating kinase assembly factor-like protein; Swiss-Prot: sp|P51949|MAT1_MOUSE CDK-activating kinase assembly factor MAT1; TrEMBL-Plants: tr|I3S4Z7|I3S4Z7_MEDTR Uncharacterized protein; Found in the gene: LotjaGi2g1v0254400_LC
GO terms
4
LotjaGi2g1v0254400_LC.3
– CDK-activating kinase assembly factor; TAIR: AT4G30820.1 cyclin-dependent kinase-activating kinase assembly factor-related / CDK-activating kinase assembly factor-like protein; Swiss-Prot: sp|P51950|MAT1_MARGL CDK-activating kinase assembly factor MAT1; TrEMBL-Plants: tr|I3S4Z7|I3S4Z7_MEDTR Uncharacterized protein; Found in the gene: LotjaGi2g1v0254400_LC
GO terms
4
LotjaGi2g1v0254400_LC.4
– CDK-activating kinase assembly factor; TAIR: AT4G30820.1 cyclin-dependent kinase-activating kinase assembly factor-related / CDK-activating kinase assembly factor-like protein; Swiss-Prot: sp|P51950|MAT1_MARGL CDK-activating kinase assembly factor MAT1; TrEMBL-Plants: tr|I3S4Z7|I3S4Z7_MEDTR Uncharacterized protein; Found in the gene: LotjaGi2g1v0254400_LC
GO terms
4
LotjaGi2g1v0254400_LC.5
– CDK-activating kinase assembly factor; TAIR: AT4G30820.1 cyclin-dependent kinase-activating kinase assembly factor-related / CDK-activating kinase assembly factor-like protein; Swiss-Prot: sp|P51950|MAT1_MARGL CDK-activating kinase assembly factor MAT1; TrEMBL-Plants: tr|I3S4Z7|I3S4Z7_MEDTR Uncharacterized protein; Found in the gene: LotjaGi2g1v0254400_LC
GO terms
4
LotjaGi2g1v0271400.1
– CDK-activating kinase assembly factor; TAIR: AT4G30820.1 cyclin-dependent kinase-activating kinase assembly factor-related / CDK-activating kinase assembly factor-like protein; Swiss-Prot: sp|P51949|MAT1_MOUSE CDK-activating kinase assembly factor MAT1; TrEMBL-Plants: tr|C6SW25|C6SW25_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0271400
GO terms
4

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0061575
Molecular function Cyclin-dependent protein serine/threonine kinase activator activity 1 10.00