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IPR027524 is a Eukaryotic translation initiation factor 3 subunit H.
<p>Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [[cite:PUB00064793], [cite:PUB00064957]]. It is a non-peptidase homologue in peptidase family M67 (MEROPS identifier M67.971).</p> <p>Results suggest that eIF3h regulates cell growth and viability, and that over-expression of the gene may provide growth advantage to prostate, breast, and liver cancer cells [[cite:PUB00010249], [cite:PUB00080897], [cite:PUB00080898]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Cellular component | Eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: eukaryotic translation initiation factor 3 subunit H-like [Glycine max] gi|356568923|ref|XP_003552657.1| | 9 | ||
| – | Eukaryotic translation initiation factor 3 subunit H; TAIR: AT1G10840.1 translation initiation factor 3 subunit H1; Swiss-Prot: sp|Q9C5Z2|EIF3H_ARATH Eukaryotic translation initiation factor 3 subunit H; TrEMBL-Plants: tr|I3SB83|I3SB83_LOTJA Eukaryotic translation initiation factor 3 subunit H; Found in the gene: LotjaGi1g1v0530600 | 12 | ||
| – | Eukaryotic translation initiation factor 3 subunit H; TAIR: AT1G10840.1 translation initiation factor 3 subunit H1; Swiss-Prot: sp|Q9C5Z2|EIF3H_ARATH Eukaryotic translation initiation factor 3 subunit H; TrEMBL-Plants: tr|I3SB83|I3SB83_LOTJA Eukaryotic translation initiation factor 3 subunit H; Found in the gene: LotjaGi1g1v0530600 | 12 | ||
| – | Eukaryotic translation initiation factor 3 subunit H; TAIR: AT1G10840.1 translation initiation factor 3 subunit H1; Swiss-Prot: sp|Q9C5Z2|EIF3H_ARATH Eukaryotic translation initiation factor 3 subunit H; TrEMBL-Plants: tr|I1N504|I1N504_SOYBN Eukaryotic translation initiation factor 3 subunit H; Found in the gene: LotjaGi4g1v0059200_LC | 4 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |