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IPR027705 is a Flotillin family.
<p>Flotillin proteins are membrane-bound chaperones that localize to lipid rafts, where they may recruit the proteins that need to be localized in lipid rafts to be active and facilitate their interaction and oligomerization. Proteins in this entry include flotillin-1 (also known as reggie-2), flotillin-2 (also known as reggie-1) and their homologues. Flotillin-1 and flotillin-2 associate with membrane microdomains known as rafts [[cite:PUB00066451]]. They play a role in various cellular processes such as insulin signaling, T cell activation, membrane trafficking, phagocytosis, and epidermal growth factor receptor signaling [[cite:PUB00066450]].</p> <p>This entry also include bacterial homologues of Flotillin-1. These bacterial proteins are found in membrane microdomains that may be equivalent to eukaryotic membrane rafts [[cite:PUB00099631]]. Similarly to eukaryotic flotillin proteins, flotillins in bacteria play an essential role in organizing and maintaining the correct architecture of the functional membrane microdomains [[cite:PUB00099632]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Flotillin-like protein 2 [Theobroma cacao] gi|508717314|gb|EOY09211.1| | 3 | ||
| – | Nodulin [Glycine max] gi|351722212|ref|NP_001237748.1| | 4 | ||
| – | Flotillin-like protein [Medicago truncatula] gi|357440565|ref|XP_003590560.1| | 7 | ||
| – | RecName: Full=Flotillin-like protein 1gi|282597660|gb|ADA83094.1| flotillin-like protein 1 [Medicago truncatula] gi|300680951|sp|D2XNQ8.1|FLOT1_MEDTR | 5 | ||
| – | Nodulin [Glycine max] gi|351722212|ref|NP_001237748.1| | 3 | ||
| – | Nodulin [Glycine max] gi|351722212|ref|NP_001237748.1| | 3 | ||
| – | Flotillin-1, putative; TAIR: AT5G25250.1 SPFH/Band 7/PHB domain-containing membrane-associated protein family; Swiss-Prot: sp|D2XNQ8|FLOT1_MEDTR Flotillin-like protein 1; TrEMBL-Plants: tr|B9IL19|B9IL19_POPTR Nodulin family protein; Found in the gene: LotjaGi1g1v0380900 | 10 | ||
| – | Flotillin-like protein 1; TAIR: AT5G25250.1 SPFH/Band 7/PHB domain-containing membrane-associated protein family; Swiss-Prot: sp|D2XNQ8|FLOT1_MEDTR Flotillin-like protein 1; TrEMBL-Plants: tr|V7AXM0|V7AXM0_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0381000 | 10 | ||
| – | Flotillin-like protein 1; TAIR: AT5G25260.1 SPFH/Band 7/PHB domain-containing membrane-associated protein family; Swiss-Prot: sp|D2XNQ8|FLOT1_MEDTR Flotillin-like protein 1; TrEMBL-Plants: tr|A0A0R0JJ08|A0A0R0JJ08_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0381100 | 11 | ||
| – | Flotillin-like protein 1; TAIR: AT5G25260.1 SPFH/Band 7/PHB domain-containing membrane-associated protein family; Swiss-Prot: sp|D2XNQ8|FLOT1_MEDTR Flotillin-like protein 1; TrEMBL-Plants: tr|Q9ZTB2|Q9ZTB2_SOYBN Nodulin; Found in the gene: LotjaGi1g1v0381100 | 10 | ||
| – | Flotillin-like protein 1; TAIR: AT5G25260.1 SPFH/Band 7/PHB domain-containing membrane-associated protein family; Swiss-Prot: sp|D2XNQ8|FLOT1_MEDTR Flotillin-like protein 1; TrEMBL-Plants: tr|A0A0R0JJ08|A0A0R0JJ08_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0381100 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03399 | CDD | 1 | 9.09 |