Description

IPR028258 is a Exocyst complex component Sec3, PIP2-binding N-terminal domain.

This is the N-terminal domain of fungal and eukaryotic Sec3 proteins. This N-terminal domain contains a cryptic pleckstrin homology (PH) fold, and all six positively charged lysine and arginine residues in the PH domain predicted to bind the phosphatidylinositol 4,5-bisphosphate (PIP2) head group are conserved. Sec3, also known as ExoC1, is a component of the exocyst complex (composed of Exoc1, Exoc2, Exoc3, Exoc4, Exoc5, Exoc6, Exoc7 and Exoc8), which mediates the tethering of post-Golgi secretory vesicles to the plasma membrane and promotes assembly of the SNARE complex for membrane fusion; the exocyst is further implicated in cell polarisation, primary ciliogenesis, cytokinesis, and tumorigenesis and metastasis [[PMID:16181645]]. The complex has an elongated shape built from packed long rods, a structure shared with the Complex Associated with Tethering Containing Helical Rods (CATCHR) family of related tethering complexes, including the Conserved Oligomeric Golgi (COG) complex and the Golgi-Associated Retrograde Protein (GARP) complex; besides their helical bundles, subunits of these complexes typically also carry a coiled-coil region at the N-terminal [[PMID:28098232], [PMID:29335562], [PMID:34061181]]. Within the exocyst, Sec3 acts as the membrane-anchoring subunit, serving as a spatial landmark on the plasma membrane for incoming secretory vesicles; it binds the C-terminal cytoplasmic domain of the glycine transporter GLYT1 and is recruited to sites of polarised membrane growth through interaction with the small GTP-binding protein Rho1p [[PMID:16181645]]. In fission yeast, polarised exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables [[PMID:22768263]]. During viral infection, Sec3 also exerts an antiviral effect against flaviviruses by sequestering elongation factor 1-alpha (EEF1A1), thereby disrupting viral RNA transcription and translation and reducing both viral RNA synthesis and viral protein production. Syntaxin-binding protein 6 (STXB6) forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis [[PMID:28198450]]. STXB6 is predicted to be a paralogue to Sec3.

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: